{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T15:15:41Z","timestamp":1788794141125,"version":"build-2803163510"},"reference-count":9,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":3365,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To characterize the clinical behavior of oral squamous cell carcinomas (OSCCA) arising in patients with pre\u2010existing oral lichen planus (OLP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Setting<\/jats:title><jats:p>Retrospective case\u2010control study. Disease\u2010free interval, time to first recurrence, subsequent therapy, and overall survival were calculated and compared between cases and controls matched for age, gender, primary site, and tumor stage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 10 identified subjects with OLP\/OSCCA, mean time from OLP diagnosis to OSCCA was 5.5 years. Three subjects suffered a local recurrence and two developed a second primary OSCCA. Mean actuarial survival for OLP patients was 119\u00a0months vs 42\u00a0months for the control patients, though this difference was not significant (<jats:italic>P<\/jats:italic> = 0.201, log\u2010rank).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>OLP\/SCCA subjects may exhibit better actuarial survival than SCCA patients despite a somewhat higher rate of local recurrence and second primary SCCA. Further study is required to characterize the behavior of OSCCA arising in pre\u2010existing OLP.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2006.09.023","type":"journal-article","created":{"date-parts":[[2007,2,26]],"date-time":"2007-02-26T10:43:42Z","timestamp":1172486622000},"page":"401-404","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Behavior of oral squamous cell carcinoma in subjects with prior lichen planus"],"prefix":"10.1002","volume":"136","author":[{"given":"Amanda A.","family":"Mu\u00f1oz","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Stanford University School of Medicine Stanford CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert I.","family":"Haddad","sequence":"additional","affiliation":[{"name":"Dana\u2010Farber Cancer Institute and Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sook\u2010Bin","family":"Woo","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Brigham and Women's Hospital Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Bhattacharyya","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology Brigham and Women's Hospital Department of Otology and Laryngology Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(03)00161-6"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(03)00305-6"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(03)00139-8"},{"issue":"5","key":"e_1_2_6_5_1","first-page":"586","article-title":"Oral lichen planus has a high rate of TP53\u00a0mutations. A study of oral mucosa in Iceland.","volume":"93","author":"Ogmundsdottir HM","year":"2002","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/ejso.2002.1302"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2004.08.011"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200302000-00030"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(98)00116-X"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2003.00125.x"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2006.09.023","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.otohns.2006.09.023","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2006.09.023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T08:51:33Z","timestamp":1760950293000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1016\/j.otohns.2006.09.023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3]]},"references-count":9,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,3]]}},"alternative-id":["10.1016\/j.otohns.2006.09.023"],"URL":"https:\/\/doi.org\/10.1016\/j.otohns.2006.09.023","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,3]]},"assertion":[{"value":"2016-05-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}