{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:27:01Z","timestamp":1761006421807,"version":"build-2065373602"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":3393,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Laryngopharyngeal reflux (LPR) is generally treated with twice\u2010daily proton\u2010pump inhibitor (PPI) therapy. In this study, the efficacy of esomeprazole 40\u00a0mg once\u2010daily together with lifestyle modifications was determined by repeated 24\u2010hour pH monitoring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Setting<\/jats:title><jats:p>A prospective study. Fortynine patients with suspected LPR underwent 24\u2010hour pH monitoring. Twenty\u2010seven of 49 patients with measurable abnormal proximal reflux reflected by a reflux area index (RAI) &gt;6.3 were treated with esomeprazole 40\u00a0mg every day, and a second pH study was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 22 of 27 patients, everyday PPI treatment reduced the RAI. Four of 5 patients with no RAI reduction reported on symptomatic relief.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In a considerable number of patients with suspected LPR, pH monitoring reveals no abnormal proximal reflux. Esomeprazole 40\u00a0mg every day together with lifestyle modifications could reach adequate acid suppression in a large number of patients. Symptom improvement is also reported by patients without measurable effects of therapy.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2006.10.011","type":"journal-article","created":{"date-parts":[[2007,2,3]],"date-time":"2007-02-03T02:46:06Z","timestamp":1170470766000},"page":"205-210","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Efficacy of once\u2010daily esomeprazole treatment in patients with laryngopharyngeal reflux evaluated by 24\u2010hour pH monitoring"],"prefix":"10.1002","volume":"136","author":[{"given":"Oliver","family":"Reichel","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery Ludwig Maximilians University Munich Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keller","family":"Jeanette","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery Ludwig Maximilians University Munich Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerd","family":"Rasp","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Klinikum Stuttgart, Katharinenhospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hjalmar","family":"Hagedorn","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery Ludwig Maximilians University Munich Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Berghaus","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery Ludwig Maximilians University Munich Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-1997(00)80033-8"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-1997(88)80060-2"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200208000-00014"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2002.125760"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200304000-00003"},{"key":"e_1_2_6_7_1","unstructured":"Full prescribing information for nexium\u00ae adverse reactions. 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