{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:34:48Z","timestamp":1761006888606,"version":"build-2065373602"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":3304,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>To develop an allergic rhinitis model via local sensitization of mice with <jats:italic>Dermatophagoides pteronyssinus<\/jats:italic> and to use the model to investigate the antiallergic effect of Bacillus Calmette\u2010Guerin (BCG).<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>BALB\/c mice were randomized to the allergic rhinitis group, the BCG group sensitized with <jats:italic>D pteronyssinus<\/jats:italic> via local sensitization for 7 weeks, or the control group. The BCG group received 1 \u00d7 10<jats:sup>5<\/jats:sup> colony\u2010forming unit\/mL of BCG seven times. We evaluated symptoms, nasal mucosa eosinophilia, serum total IgE, cytokines, and eosinophilia in bronchoalveolar lavage fluid.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>In the allergic rhinitis group, allergy symptoms (<jats:italic>P<\/jats:italic> &lt; 0.001), eosinophil count (<jats:italic>P<\/jats:italic> &lt; 0.001), total IgE (<jats:italic>P<\/jats:italic> &lt; 0.001), inflammatory cells (<jats:italic>P<\/jats:italic> &lt; 0.01), and IL\u201013 (<jats:italic>P<\/jats:italic> = 0.046) increased and interferon \u03b3 (IFN\u2010\u03b3) (<jats:italic>P<\/jats:italic> &lt; 0.001) decreased compared with the control group. In the BCG group, allergy symptoms (<jats:italic>P<\/jats:italic> &lt; 0.001), eosinophil count (<jats:italic>P<\/jats:italic> &lt; 0.001), and inflammatory cells (<jats:italic>P<\/jats:italic> &lt; 0.01) decreased and IFN\u2010\u03b3 (<jats:italic>P<\/jats:italic> = 0.031) increased compared with the allergic rhinitis group.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>In an allergic rhinitis animal model developed via local sensitization of mice with <jats:italic>D pteronyssinus<\/jats:italic>, BCG was shown to exhibit an antiallergic effect.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2006.10.016","type":"journal-article","created":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T07:10:45Z","timestamp":1178003445000},"page":"720-725","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Effect of Bacillus Calmette\u2010Guerin in a Mouse Model of Allergic Rhinitis"],"prefix":"10.1002","volume":"136","author":[{"given":"Soo Whan","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery College of Medicine The Catholic University of Korea Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Won","family":"Yeo","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery College of Medicine The Catholic University of Korea Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.115569"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)78276-6"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0019-2805.2002.01377.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.5.2516"},{"key":"e_1_2_6_6_1","first-page":"276","article-title":"House dust mite allergic rhinitis model in C57BL\/6\u00a0mice","volume":"43","author":"Yun JB","year":"2000","journal-title":"Korean J Otolaryngol"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.130048"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(98)70193-9"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62201-6"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200308-1094OC"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(01)00496-0"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2004.00517.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2000.15.3.265"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200210000-00021"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.187.4.561"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2006.10.016","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.otohns.2006.10.016","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2006.10.016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:30:43Z","timestamp":1760956243000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1016\/j.otohns.2006.10.016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,5]]}},"alternative-id":["10.1016\/j.otohns.2006.10.016"],"URL":"https:\/\/doi.org\/10.1016\/j.otohns.2006.10.016","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"type":"print","value":"0194-5998"},{"type":"electronic","value":"1097-6817"}],"subject":[],"published":{"date-parts":[[2007,5]]},"assertion":[{"value":"2016-05-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}