{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:16:23Z","timestamp":1778717783555,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":3334,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the effect of mitomycin on the repair of acquired subglottic stenosis and to define the optimal concentration of mitomycin that would minimize restenosis after repair.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design And Setting<\/jats:title><jats:p>A randomized prospective model was used in which 20 ferrets (<jats:italic>Mustela putorius furo<\/jats:italic>) underwent simulated intubation injury that was then treated with CO<jats:sub>2<\/jats:sub> laser lysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Comparison of cross\u2010sectional airway areas, after stenosis repair, showed no significant differences between control and mitomycin treatment groups. Comparison of histologic scores for both inflammation and mucosalization yielded no difference between control and treatment animals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Mitomycin C appeared to have no benefit when placed after repair of an acquired stenosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>This study closely models the injury experienced by children with acquired subglottic stenosis. These data provide clear evidence that mitomycin is limited in its effect on established wounds and help further define its role as an adjuvant for surgery in the aerodigestive tract.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2006.10.037","type":"journal-article","created":{"date-parts":[[2007,4,5]],"date-time":"2007-04-05T07:11:57Z","timestamp":1175757117000},"page":"653-657","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Refining indications for the use of mitomycin C using a randomized controlled trial with an animal model"],"prefix":"10.1002","volume":"136","author":[{"given":"Joseph","family":"Shvidler","sequence":"first","affiliation":[{"name":"Tripler Army Medical Center Honolulu HI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nici E.","family":"Bothwell","sequence":"additional","affiliation":[{"name":"Tripler Army Medical Center Honolulu HI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Cable","sequence":"additional","affiliation":[{"name":"Tripler Army Medical Center Honolulu HI"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2001.112199"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2002.124705"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-1997(00)80037-5"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2003.09.018"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200309000-00015"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.127.10.1260"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-7258(97)00088-0"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M205495200"},{"key":"e_1_2_10_10_1","first-page":"405","article-title":"Enzymology of mitomycin C metabolic activation in tumour tissue: implications for enzyme\u2010directed bioreductive drug development","volume":"56","author":"Cummings J","year":"1998","journal-title":"Biochem Pharmacol"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199910000-00009"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/otot.2002.29189"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/em.2850250103"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00917996"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002341-200003000-00006"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5876(02)00367-1"},{"key":"e_1_2_10_17_1","first-page":"341","article-title":"Pterygium surgery with mitomycin\u2010C: ten\u2010year results","volume":"32","author":"Anduze AL","year":"2001","journal-title":"Ophthalmic Surg Lasers"},{"key":"e_1_2_10_18_1","first-page":"100","article-title":"Intraoperative application of topical mitomycin C 0.05% for pterygium surgery","volume":"96","author":"Rodriguez JA","year":"2004","journal-title":"Bol Asoc Med P R"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200404000-00028"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949910801106"},{"key":"e_1_2_10_21_1","first-page":"703","article-title":"RNA interference targeting transforming growth factor\u2010beta type II receptor suppresses ocular inflammation and fibrosis","volume":"10","author":"Nakamura H","year":"2004","journal-title":"Mol Vis"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.02-0978"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-1627"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2006.10.037","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.otohns.2006.10.037","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2006.10.037","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T13:20:09Z","timestamp":1760966409000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1016\/j.otohns.2006.10.037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,4]]}},"alternative-id":["10.1016\/j.otohns.2006.10.037"],"URL":"https:\/\/doi.org\/10.1016\/j.otohns.2006.10.037","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,4]]},"assertion":[{"value":"2016-05-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}