{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T23:56:21Z","timestamp":1773273381335,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":3365,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Over the past year at least 10 case series and several case reports on osteonecrosis of the jaw (ONJ) have been published with most found in the oral surgery literature. This clinical entity is largely unknown to head and neck surgeons.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective chart review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 479 charts were reviewed, identifying 25\u00a0individuals meeting inclusion criteria. Mean age was 63.4 (standard deviation, 9.9) years; 40% were female. Multiple myeloma was the most common comorbidity. Twenty\u2010five patients were treated with bisphosphonates for 4.4 years (range, 1 to 8 years); most commonly pamidronate before ONJ diagnosis. Forty\u2010two percent (10) took steroids within the month before diagnosis. Fifty\u2010two percent (11) underwent dental work before developing ONJ.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These data reflect the importance of awareness of the possibility of ONJ with bisphosphonate therapy.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2006.11.008","type":"journal-article","created":{"date-parts":[[2007,2,26]],"date-time":"2007-02-26T10:43:42Z","timestamp":1172486622000},"page":"396-400","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Bisphosphonates and jaw osteonecrosis: The UAMS experience"],"prefix":"10.1002","volume":"136","author":[{"given":"Brett M.","family":"Clarke","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Little Rock AR"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennings","family":"Boyette","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Little Rock AR"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emre","family":"Vural","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Little Rock AR"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James Y.","family":"Suen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Little Rock AR"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elias J.","family":"Anaissie","sequence":"additional","affiliation":[{"name":"Myeloma Institute for Research and Therapy Little Rock AR"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Brendan C.","family":"Stack","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Little Rock AR"},{"name":"University of Arkansas for Medical Sciences Little Rock AR"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-144-10-200605160-00009"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(03)00720-1"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2005.01.010"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2004.02.004"},{"key":"e_1_2_6_6_1","unstructured":"Package insert revisions re: Osteonecrosis of the jaw: Zometa (zoledronic acid) injection and Aredia (pamidronate disodium) injection. 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