{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:14:15Z","timestamp":1789604055943,"version":"build-2803163510"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":3304,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:sec><jats:title>OBJECTIVES<\/jats:title><jats:p>This study investigates the efficacy of recombinant fusogenic VSV [rVSV\u2010NDV\/F(L289A) or rVSV\u2010F] in the treatment of head and neck squamous cell carcinoma (HNSCC).<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND SETTING<\/jats:title><jats:p>The in vitro replication and cytotoxicity of rVSV\u2010F were studied in two human SCC cell lines, in one murine SCC cell line, and in human keratinocytes. The effects on tumor size and animal survival were investigated following in vivo rVSV\u2010F treatment of floor\u2010of\u2010mouth tumor model C3H\/HeJ mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Recombinant VSV\u2010F preferentially induced rapid syncytia formation, and replicated in (<jats:italic>P<\/jats:italic> &lt; 0.04) and killed (<jats:italic>P<\/jats:italic> &lt; 1 \u00d7 10<jats:sup>\u201013<\/jats:sup>) all three SCC lines tested. The virus had no observable effect on human keratinocytes. Tumor size was smaller (<jats:italic>P<\/jats:italic> &lt; 0.03) and overall survival was better (<jats:italic>P<\/jats:italic> &lt; 0.001) for treated animals than for control animals.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION\/SIGNIFICANCE<\/jats:title><jats:p>Recombinant VSV\u2010F confers a modest survival benefit for HNSCC in this orthotopic murine model. This oncolytic virus holds promise as a novel cancer treatment for recurrent HNSCC.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2006.11.046","type":"journal-article","created":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T07:10:45Z","timestamp":1178003445000},"page":"811-817","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Fusogenic Vesicular Stomatitis Virus for the Treatment of Head and Neck Squamous Carcinomas"],"prefix":"10.1002","volume":"136","author":[{"given":"Edward J.","family":"Shin","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Mount Sinai School of Medicine New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime I.","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Mount Sinai School of Medicine New York 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