{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T10:41:05Z","timestamp":1792060865015,"version":"4.4.0"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":3273,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Esthesioneuroblastoma (ENB) is a rare tumor of the olfactory epithelium. The objective of this study was to evaluate treatment modalities including surgery, IMRT, and chemotherapy and patient outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>A retrospective analysis was performed on a total of 21 patients. Therapy included craniofacial resection (CFR), radiotherapy, chemotherapy, or a combination of these methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median follow\u2010up period was 47\u00a0months. Surgery was performed in 90.4% of cases; radiotherapy was performed adjuvantly in 15 (72.7%) patients. Surgery, radiotherapy, and chemotherapy were administered to 7 (33.3%) patients. Eight (38.3%) patients had local recurrence. The 5\u2010year crude overall survival was 71.4% and actuarial 5\u2010year overall survival was 58% with confidence interval (CI, 25 and 81, respectively). The 5\u2010year crude disease\u2010free survival rate was 59% and the 5\u2010year actuarial disease\u2010free survival rate was 62% (CI, 28 and 83, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Multidisciplinary therapy of ENB should be considered, especially for Kadish C and high\u2010grade lesions. Craniofacial resection (CFR), Intensity modulated radiation therapy (IMRT), and chemotherapy should be investigated in a multi\u2010institution trial of ENB.<\/jats:p><jats:p>\u00a9 2007 American Academy of Otolaryngology\u2010Head and Neck Surgery Foundation. All rights reserved.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2006.11.051","type":"journal-article","created":{"date-parts":[[2007,6,20]],"date-time":"2007-06-20T07:19:19Z","timestamp":1182323959000},"page":"998-1002","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Combined modality therapy of esthesioneuroblastoma"],"prefix":"10.1002","volume":"136","author":[{"given":"J. Nicolas","family":"McLean","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Emory University School of Medicine Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunjay R.","family":"Nunley","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Emory University School of Medicine Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Klass","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Emory University School of Medicine Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Emory University School of Medicine Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00fcller","family":"Susan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Emory University School of Medicine Atlanta GA"},{"name":"Department of Pathology and Laboratory Medicine Emory University School of Medicine Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. S. Johnstone","family":"Peter","sequence":"additional","affiliation":[{"name":"Department of Winship Cancer Institute Emory University School of Medicine Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,17]]},"reference":[{"issue":"1","key":"e_1_2_6_2_1","first-page":"12","article-title":"Cancer of the nasal cavity and paranasal sinuses: a series of 115 patients.","volume":"36","author":"Svane\u2010Knudsen V","year":"1998","journal-title":"Rhinology"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(20000401)88:7<1728::AID-CNCR29>3.0.CO;2-7"},{"key":"e_1_2_6_4_1","first-page":"3749","volume-title":"Cummings Otolarynsology Head and Neck Surgery","year":"2005"},{"issue":"4","key":"e_1_2_6_5_1","first-page":"2683","article-title":"Esthesioneuroblastoma: a general review of the cases published since the discovery of the tumour in 1924.","volume":"17","author":"Broich G","year":"1997","journal-title":"Anticancer Res"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200103000-00020"},{"issue":"1","key":"e_1_2_6_7_1","first-page":"1","article-title":"Outcome and analysis of the surgical management of esthesioneuroblastoma.","volume":"26","author":"Irish J","year":"1997","journal-title":"J Otolaryngol"},{"key":"e_1_2_6_8_1","unstructured":"http:\/\/www.emedicine.com\/med\/topic748.htm"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3171\/foc.2002.12.5.5"},{"key":"e_1_2_6_10_1","first-page":"240","volume-title":"Tumors of the upper respiratory tract and ear","author":"Hyams VJ","year":"1988"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0347(200009)22:6<550::AID-HED2>3.0.CO;2-0"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197603)37:3<1571::AID-CNCR2820370347>3.0.CO;2-L"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199208000-00001"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199011000-00013"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-199805000-00045"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00020840-200304000-00009"},{"key":"e_1_2_6_17_1","first-page":"66","volume-title":"Pathology and Genetics of Head and Neck Tumours","author":"World Health Organization Classification of Tumours","year":"2005"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00066-005-1362-2"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200004000-00018"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-16000"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200312000-00005"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-199305000-00002"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.1107"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/028418600430833"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(93)90457-7"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2003.10.010"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(01)00558-7"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2006.11.051","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.otohns.2006.11.051","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2006.11.051","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T08:54:06Z","timestamp":1760950446000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1016\/j.otohns.2006.11.051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["10.1016\/j.otohns.2006.11.051"],"URL":"https:\/\/doi.org\/10.1016\/j.otohns.2006.11.051","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,6]]},"assertion":[{"value":"2016-05-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}