{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:26:53Z","timestamp":1761006413294,"version":"build-2065373602"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":3273,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the effect of timing of intraoperative parathormone (iPTH) samples and 25\u2010hydroxyvitamin D (25\u2010OHD) status on decision\u2010making during parathyroidectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 77 patients with primary hyperparathyroidism and iPTH levels (preincision, preremoval, 5 (T5) and 10 (T10) minutes postremoval) performed during parathyroidectomy were reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010one percent of patients were 25\u2010OHD insufficient. We noted a significant correlation between preoperative 25\u2010OHD and preincision iPTH (<jats:italic>P<\/jats:italic> = 0.002) but not iPTH at postremoval levels (T5, <jats:italic>P<\/jats:italic> = 0.89; T10, <jats:italic>P<\/jats:italic> = 0.42). When compared with preincision iPTH, the use of either the higher preincision or preremoval iPTH baseline significantly improves the assay sensitivity from 83% to 93% at T5 (<jats:italic>P<\/jats:italic> = 0.01) and 87% to 97% at T10 (<jats:italic>P<\/jats:italic> = 0.02). Surgical cure was obtained in 98% of patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Obtaining preremoval iPTH allowed earlier decision with respect to operative completion in 38% of cases. 25\u2010OHD status does not appear to significantly affect interpretation of iPTH levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>Obtaining both baseline levels significantly improves sensitivity in iPTH monitoring.<\/jats:p><jats:p>\u00a9 2007 American Academy of Otolaryngology\u2010Head and Neck Surgery Foundation. 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