{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T19:39:26Z","timestamp":1788205166262,"version":"build-2803163510"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":3304,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>To assess and differentiate the health\u2010related quality of life (HR\u2010QoL) in patients with hereditary hemorrhagic telangiectasia (HHT).<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND SETTING<\/jats:title><jats:p>A prospective, open, cross\u2010sectional questionnaire\u2010based study (including the Short Form\u201036 Health Survey [SF\u201036]) performed by a tertiary care center.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>A total of 77 patients (36 females) were included. Except for one domain (bodily pain), the scores for all scales of the SF\u201036 were significantly reduced in comparison with normative data. The duration of epistaxis, the presence of hepatic involvement and gastrointestinal bleeding, and the number of visible telangiectases correlated with lower scores on several scales of the SF\u201036. Unexpectedly, the frequency of epistaxis did not correlate with any scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The duration of epistaxis, liver involvement, gastrointestinal bleeding, and the number of visible telangiectases have a major influence on the HR\u2010QoL in HHT whereby the frequency of epistaxis seems to play a minor role.<\/jats:p><\/jats:sec><jats:sec><jats:title>SIGNIFICANCE<\/jats:title><jats:p>The data presented have an impact on therapeutic decisions, medical expert opinions, and research funding.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2006.12.019","type":"journal-article","created":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T07:10:45Z","timestamp":1178003445000},"page":"726-733","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":84,"title":["Health\u2010Related Quality of Life in Hereditary Hemorrhagic Telangiectasia"],"prefix":"10.1002","volume":"136","author":[{"given":"Urban W.","family":"Geisthoff","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Hospitals of the University of the Saarland Homburg\/Saar Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katinka","family":"Heckmann","sequence":"additional","affiliation":[{"name":"Department of Orthodontics Hospitals of the University of the Saarland Homburg\/Saar Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"D'Amelio","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy Hospitals of the University of the Saarland Homburg\/Saar Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Gr\u00fcnewald","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Hospitals of the University of the Saarland Homburg\/Saar Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Kn\u00f6bber","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Hospitals of the University of the Saarland Homburg\/Saar Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Falkai","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy Hospitals of the University of the Saarland Homburg\/Saar Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochem","family":"K\u00f6nig","sequence":"additional","affiliation":[{"name":"Institute of Medical Biometry, Epidemiology, und Informatics Johannes Gutenberg University Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,17]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199510053331407"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(20000306)91:1<66::AID-AJMG12>3.0.CO;2-P"},{"issue":"2","key":"e_1_2_5_4_1","first-page":"114","article-title":"Heredit\u00e4re h\u00e4morrhagische Teleangiektasie (Morbus Osler)","volume":"50","author":"Geisthoff UW","year":"2002","journal-title":"Eine interdisziplin\u00e4re Herausforderung. 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A population\u2010based study on prevalence and mortality among Danish HHT patients [in Danish]","volume":"162","author":"Kjeldsen AD","year":"2000","journal-title":"Ugeskr Laeger"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/194589240501900112"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-004-7865-y"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-004-0911-0"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/194589240501900113"},{"key":"e_1_2_5_14_1","volume-title":"SF\u2010Fragebogen zum Gesundheitszustand, Handanweisung","author":"Bullinger M","year":"1998"},{"key":"e_1_2_5_15_1","volume-title":"SF\u201036 health survey manual and interpretation guide","author":"Ware JJ","year":"1993"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.324.7351.1417"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.40.7.494"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.305.6846.160"},{"key":"e_1_2_5_19_1","first-page":"333","article-title":"On a family form of recurring epistaxis, associated with multiple telangiectases of the skin and mucous membranes","volume":"12","author":"Osler W","year":"1901","journal-title":"Johns Hopkins Hospital Bulletin"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2006.12.019","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.otohns.2006.12.019","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2006.12.019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:30:27Z","timestamp":1760956227000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1016\/j.otohns.2006.12.019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,5]]}},"alternative-id":["10.1016\/j.otohns.2006.12.019"],"URL":"https:\/\/doi.org\/10.1016\/j.otohns.2006.12.019","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,5]]},"assertion":[{"value":"2016-05-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}