{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T06:47:45Z","timestamp":1769237265150,"version":"3.49.0"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":3304,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>To evaluate sensitivity and specificity of frozen\u2010section biopsy in the diagnosis of acute invasive fungal rhinosinusitis (AIFRS).<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND SETTING<\/jats:title><jats:p>Retrospective chart review of all patients treated for AIFRS at the University of Miami between 1993 and 2005. Twenty patients with the clinical diagnosis of AIFRS were identified. Histopathological data were collected to evaluate the use of frozen\u2010section biopsy to diagnose the disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Permanent pathology sections were positive for AIFRS in all specimens. Frozen\u2010section biopsies were positive for fungal features in all but five cases (four with <jats:italic>Mucor<\/jats:italic> and one with <jats:italic>Aspergillus<\/jats:italic>). High positive predictive values were found for both fungal types and for both sets of patients (bedside and intraoperative).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Frozen\u2010section biopsy is a useful tool for rapid and effective diagnosis in patients with suspected AIFRS. A positive frozen\u2010section result is highly predictive of invasive disease and merits prompt surgical intervention.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2007.01.002","type":"journal-article","created":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T07:10:45Z","timestamp":1178003445000},"page":"714-719","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":83,"title":["Frozen\u2010Section Biopsy Analysis for Acute Invasive Fungal Rhinosinusitis"],"prefix":"10.1002","volume":"136","author":[{"given":"Murtaza T.","family":"Ghadiali","sequence":"first","affiliation":[{"name":"University of Miami\/Jackson Memorial Hospital Department of Otolaryngology\/Head and Neck Surgery Miami FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan A.","family":"Deckard","sequence":"additional","affiliation":[{"name":"University of Miami Miller School of Medicine Miami FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uzma","family":"Farooq","sequence":"additional","affiliation":[{"name":"Department of Pathology Miami FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Astor","sequence":"additional","affiliation":[{"name":"University of Miami\/Jackson Memorial Hospital Department of Otolaryngology\/Head and Neck Surgery Miami FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phillip","family":"Robinson","sequence":"additional","affiliation":[{"name":"Department of Pathology Miami FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roy R.","family":"Casiano","sequence":"additional","affiliation":[{"name":"University of Miami\/Jackson Memorial Hospital Department of Otolaryngology\/Head and Neck Surgery Miami FL"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(00)80010-9"},{"key":"e_1_2_7_3_1","first-page":"179","volume-title":"Diseases of the sinuses","author":"Dhong H","year":"2001"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.5858\/2001-125-0375-HFOZ"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-4453(98)91921-1"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1258\/002221503322542854"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/0031302031000123173"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)70804-9"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002341-200101000-00012"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2005.12.018"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/73.1.13"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.2307\/2685046"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.156.3.337"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199707000-00004"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(199910)21:4<300::AID-DC15>3.0.CO;2-T"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0339(200008)23:2<97::AID-DC6>3.0.CO;2-P"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-0507.1999.00470.x"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2007.01.002","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.otohns.2007.01.002","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2007.01.002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:30:30Z","timestamp":1760956230000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1016\/j.otohns.2007.01.002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,5]]}},"alternative-id":["10.1016\/j.otohns.2007.01.002"],"URL":"https:\/\/doi.org\/10.1016\/j.otohns.2007.01.002","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,5]]},"assertion":[{"value":"2016-05-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}