{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T20:22:15Z","timestamp":1791145335594,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":3243,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>\n                      Three of four paraganglioma syndromes (PGLs) have been characterized on a molecular genetic basis. PGL 1 is associated with mutations of the succinate dehydrogenase subunit D (\n                      <jats:italic>SDHD<\/jats:italic>\n                      ) gene, PGL 3 is caused by\n                      <jats:italic>SDHC<\/jats:italic>\n                      gene mutations, and PGL 4 is caused by\n                      <jats:italic>SDHB<\/jats:italic>\n                      gene mutations. The objective of this study was to investigate whether PGLs are associated with malignant head and neck paragangliomas (HNPs).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>STUDY DESIGN AND SETTING<\/jats:title>\n                    <jats:p>\n                      Through November 2005, we screened 195 HNP patients for mutations of the genes\n                      <jats:italic>SDHB, SDHC<\/jats:italic>\n                      , and\n                      <jats:italic>SDHD<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      We detected 5\n                      <jats:italic>SDHC<\/jats:italic>\n                      , 13\n                      <jats:italic>SDHB<\/jats:italic>\n                      , and 45\n                      <jats:italic>SDHD<\/jats:italic>\n                      gene mutations. In seven\n                      <jats:italic>SDHB<\/jats:italic>\n                      mutation carriers, there were distant metastases. No signs of metastases were found in\n                      <jats:italic>SDHC<\/jats:italic>\n                      and\n                      <jats:italic>SDHD<\/jats:italic>\n                      patients. One patient with a sporadic HNP presented with locally metastatic disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>\n                      <jats:italic>SDHB<\/jats:italic>\n                      mutations are associated with a high rate of malignant HNPs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>SIGNIFICANCE<\/jats:title>\n                    <jats:p>\n                      In\n                      <jats:italic>SDHB<\/jats:italic>\n                      patients, a three\u2010body region imaging and scintigraphy or DOPA\u2010PET must be performed to exclude metastases.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.otohns.2007.01.015","type":"journal-article","created":{"date-parts":[[2007,6,26]],"date-time":"2007-06-26T07:18:32Z","timestamp":1182842312000},"page":"126-129","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":122,"title":["Malignant Head and Neck Paragangliomas in\n                    <i>SDHB<\/i>\n                    Mutation Carriers"],"prefix":"10.1002","volume":"137","author":[{"given":"Carsten Christof","family":"Boedeker","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery University of Freiburg Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hartmut P. H.","family":"Neumann","sequence":"additional","affiliation":[{"name":"Department of Nephrology University of Freiburg Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Maier","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery University of Freiburg Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birke","family":"Bausch","sequence":"additional","affiliation":[{"name":"Department of Nephrology University of Freiburg Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Schipper","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery University of Freiburg Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerd J\u00fcrgen","family":"Ridder","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery University of Freiburg Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.8.943"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459989010200413"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2004.09.024"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-004-2154-z"},{"key":"e_1_2_10_6_1","doi-asserted-by":"crossref","unstructured":"BrouwersFM EisenhoferG TaoJJ et al.High frequency of SDHB germline mutations in patients with malignant catecholamine producing paragangliomas: implications for genetic testing.J Clin Endocrinol Metab2006;Aug 15 (Epub ahead of 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