{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T08:40:47Z","timestamp":1761986447934,"version":"build-2065373602"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,11,22]],"date-time":"2016-11-22T00:00:00Z","timestamp":1479772800000},"content-version":"vor","delay-in-days":3401,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>To study the risks of vial contamination and infection associated with immunotherapy vial mixing and injection.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN<\/jats:title><jats:p>Retrospective review of patient immunotherapy records from January 2000\u2010June 2006.<\/jats:p><\/jats:sec><jats:sec><jats:title>SETTING<\/jats:title><jats:p>Tertiary care outpatient otolaryngology clinic.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Two hundred seventy\u2010two patients were given 26,795\u00a0injections (average of 98.5\u00a0injections per patient). Three hundred ninety\u2010nine total local reactions were reported by the subjects (1.49%; 95% CI 1.34%\u20101.63%). The majority (82%) of the local reactions occurred during escalation dosing. There were 23 episodes of wheezing or shortness of breath after injections (9.6 of 10,000). No patients experienced anaphylaxis. There was no documented skin or systemic infections as a result of the allergy injections. None of the patients experienced fever, discharge from the injection site, cellulitis, or required antibiotics.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>This review of immunotherapy records revealed no complications of infection from the preparation and administration of immunotherapy performed in an outpatient clinic.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2007.02.012","type":"journal-article","created":{"date-parts":[[2007,7,31]],"date-time":"2007-07-31T07:27:28Z","timestamp":1185866848000},"page":"243-245","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Allergen Vial Mixing and Immunotherapy: Risks of Infections and Vial Contamination"],"prefix":"10.1002","volume":"137","author":[{"given":"P. Chase","family":"Lay","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Southern Illinois University School of Medicine Springfield IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Bass","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Southern Illinois University School of Medicine Springfield IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra Y.","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Johns Hopkins School of Medicine Baltimore MD"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,11,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.2500\/108854195778667800"},{"key":"e_1_2_8_3_1","first-page":"2461","volume-title":"US Pharmacopeia 28","author":"US Pharmacopeial Convention, Inc.","year":"2004"},{"key":"e_1_2_8_4_1","first-page":"5","article-title":"Joint commissions perspectives on patient safety","volume":"6","year":"2006","journal-title":"Jt Comm Perspect"},{"key":"e_1_2_8_5_1","first-page":"200","volume-title":"Allergy in ENT practice: a basic guide","author":"King HC","year":"1998"},{"key":"e_1_2_8_6_1","first-page":"291","volume-title":"Allergy in ENT practice: a basic guide","author":"King HC","year":"1998"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0546(04)79255-1"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(90)90165-Z"},{"key":"e_1_2_8_9_1","first-page":"52","article-title":"Non\u2010fatal systemic reactions to subcutaneous immunotherapy: A 20\u2010year experience comparison of two 10\u2010year periods","volume":"36","author":"Ragusa VF","year":"2004","journal-title":"Eur Ann Allergy Clin Immunol"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.10.010"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(96)70162-8"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(81)90047-6"},{"key":"e_1_2_8_13_1","first-page":"535","article-title":"Effects of diluents on skin tests","volume":"51","author":"Menardo JL","year":"1983","journal-title":"Ann Allergy"},{"key":"e_1_2_8_14_1","first-page":"177","article-title":"Immediate adverse reactions to immunotherapy","volume":"13","author":"Can D","year":"2003","journal-title":"J Inmestic Allerg Clin Immunol"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000074307"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2007.02.012","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.otohns.2007.02.012","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2007.02.012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T12:52:13Z","timestamp":1760964733000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1016\/j.otohns.2007.02.012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,8]]}},"alternative-id":["10.1016\/j.otohns.2007.02.012"],"URL":"https:\/\/doi.org\/10.1016\/j.otohns.2007.02.012","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"type":"print","value":"0194-5998"},{"type":"electronic","value":"1097-6817"}],"subject":[],"published":{"date-parts":[[2007,8]]},"assertion":[{"value":"2006-09-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2007-02-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-11-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}