{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T18:09:46Z","timestamp":1778522986510,"version":"3.51.4"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,11,22]],"date-time":"2016-11-22T00:00:00Z","timestamp":1479772800000},"content-version":"vor","delay-in-days":3401,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:sec><jats:title>OBJECTIVES<\/jats:title><jats:p>To establish a preoperative diagnostic system and examine prognostic factors for Kimura disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN<\/jats:title><jats:p>Retrospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>SETTING<\/jats:title><jats:p>Hospital records were reviewed for nine cases of Kimura disease treated in our department. Preoperative eosinophil counts for 74 cases with untreated malignancy in the parotid gland were also examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Parotid swelling with inhomogeneities and subcutaneous invasion on magnetic resonance imaging and eosinophils &gt; 10.5 percent in Asian patients clearly indicates Kimura disease. Eosinophils &gt; 50 percent, serum IgE levels &gt; 10,000\u00a0IU\/mL, and multifocal lesions outside salivary glands are prognostic factors suggesting disease recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>A preoperative decision based on our diagnostic criteria and prognostic factors should lead to better therapeutic outcomes for Kimura disease, for which a definitive treatment policy has never been determined.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2007.03.027","type":"journal-article","created":{"date-parts":[[2007,7,31]],"date-time":"2007-07-31T07:27:28Z","timestamp":1185866848000},"page":"306-311","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Kimura Disease: Diagnosis and Prognostic Factors"],"prefix":"10.1002","volume":"137","author":[{"given":"Hiroshi","family":"Iwai","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Kansai Medical 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