{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:35:44Z","timestamp":1790861744331,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":3151,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Inner ear inflammation triggered by CMV infection may play a role in CMV\u2010related auditory pathogenesis. The purpose of the study was to determine if a virally encoded macrophage inflammatory protein played a role in CMV\u2010related hearing loss.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Mutagenesis was performed with deletion of a guinea pig CMV macrophage inflammatory protein. Intracochlear inoculations were performed on three groups of animals (n = 18). Group 1 received sterile viral media, Group 2 received wild\u2010type CMV virus, and Group 3 received \u201cknockout\u201d (KO) virus with a deleted immunomodulation gene. Baseline and postinoculation ABRs were obtained. ELISA and PCR were performed and temporal bones examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects<\/jats:title><jats:p>Eighteen guinea pigs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The KO group had significantly better hearing than the WT group. There were no significant differences between the KO and sham groups. The WT group had significant hearing loss at all frequencies. Inflammation and fibrosis were noted in the WT temporal bones only.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Virally encoded macrophage inflammatory proteins appear to play a significant role in CMV\u2010related hearing loss.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2007.03.044","type":"journal-article","created":{"date-parts":[[2007,11,14]],"date-time":"2007-11-14T10:28:06Z","timestamp":1195036086000},"page":"612-618","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Macrophage inflammatory proteins in cytomegalovirus\u2010related inner ear injury"],"prefix":"10.1002","volume":"137","author":[{"given":"Scott A.","family":"Schraff","sequence":"first","affiliation":[{"name":"Department of Pediatric Otolaryngology\u2013Head and Neck Surgery Cincinnati Children's Hospital Medical Center Cincinnati OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R.","family":"Schleiss","sequence":"additional","affiliation":[{"name":"Division of Pediatric Infectious Diseases Center for Infectious Diseases and Microbiology Translational Research University of Minnesota Department of Pediatrics Minneapolis MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David K.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Pediatric Otolaryngology\u2013Head and Neck Surgery Cincinnati Children's Hospital Medical Center Cincinnati OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jareen","family":"Meinzen\u2010Derr","sequence":"additional","affiliation":[{"name":"Department of Pediatric Otolaryngology\u2013Head and Neck Surgery Cincinnati Children's Hospital Medical Center Cincinnati OH"},{"name":"Center for Epidemiology and Biostatistics Cincinnati Children's Hospital Medical Center Cincinnati OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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