{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T06:07:11Z","timestamp":1792735631694,"version":"4.5.0"},"reference-count":11,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":3120,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To test the feasibility of laser tissue welding as a method of creating an endonasal tissue bond for the purpose of cerebrospinal fluid leak repair.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Setting<\/jats:title><jats:p>An 808\u00a0nm diode laser was used with a 42% albumin solder to create laser welds in sheep nasal septal mucosa, periosteum, and in situ rabbit maxillary sinus mucosa. Each condition was tested five times. Groups were compared with Kruskal\u2010Wallis nonparametric analysis of variance (ANOVA) and post\u2010hoc multiple\u2010comparisons testing with the Bonferroni test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The burst pressures of sheep septal mucosa (34.88 \u00b1 3.49\u00a0mmHg) and periosteum (30.02 \u00b1 2.23\u00a0mmHg) were significantly higher than suture repair. A burst pressure of 69.58 \u00b1 2.85\u00a0mmHg was achieved in rabbit in situ maxillary sinus mucosa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Laser welding is capable of producing tissue bonds whose burst strength exceeds that of human intracranial pressure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>This is the first study to examine the feasibility of laser tissue welding in endonasal tissues. The ability to produce instant transnasal tissue bonds with burst pressures that exceed human intracranial pressure make this technology ideal for cerebrospinal fluid leak repair.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2007.05.060","type":"journal-article","created":{"date-parts":[[2007,11,14]],"date-time":"2007-11-14T07:12:14Z","timestamp":1195024334000},"page":"810-814","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Laser\u2010assisted cerebrospinal fluid leak repair: An animal model to test feasibility"],"prefix":"10.1002","volume":"137","author":[{"given":"Benjamin S.","family":"Bleier","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery Hospital of the University of Pennsylvania Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James N.","family":"Palmer","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery Hospital of the University of Pennsylvania Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony M.","family":"Sparano","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery Hospital of the University of Pennsylvania Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noam A.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery Hospital of the University of Pennsylvania Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-59989670005-0"},{"key":"e_1_2_8_3_1","first-page":"233","article-title":"Vein anastomosis by electrocoaptive union","volume":"13","author":"Sigel B","year":"1962","journal-title":"Surg Forum"},{"key":"e_1_2_8_4_1","first-page":"28","article-title":"Blood vessel anastamosis by laser and other biomedical applications","volume":"1","author":"Yahr WZ","year":"1966","journal-title":"J Assoc Adv Med Instrum"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archfaci.3.3.207"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0741-5214(90)90219-Z"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2005.103.1.0087"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(99)80206-4"},{"issue":"3","key":"e_1_2_8_9_1","first-page":"176","article-title":"Effect of laser wavelength and protein solder concentration on acute tissue repair using laser welding: initial results in a canine ureter model.","volume":"3","author":"Wright EJ","year":"1997","journal-title":"Tech Urol"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.1900100610"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.1900090512"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)67263-1"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2007.05.060","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.otohns.2007.05.060","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2007.05.060","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T08:55:29Z","timestamp":1760950529000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1016\/j.otohns.2007.05.060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11]]},"references-count":11,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,11]]}},"alternative-id":["10.1016\/j.otohns.2007.05.060"],"URL":"https:\/\/doi.org\/10.1016\/j.otohns.2007.05.060","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,11]]},"assertion":[{"value":"2007-01-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2007-05-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-05-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}