{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:09:37Z","timestamp":1761894577515,"version":"build-2065373602"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":3181,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:sec><jats:title>OBJECTIVES<\/jats:title><jats:p>To report the oncology and functional outcomes of transoral laser microsurgery (TLM) for untreated glottic carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN<\/jats:title><jats:p>A 2 center prospective case series analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>SETTING<\/jats:title><jats:p>Academic, tertiary referral centers.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Seventy\u2010six patients underwent TLM. Pathologic T stages were: T1, 45 (59%); T2, 21 (28%); T3, 5 (7%); and T4, 5 (7%). Five (7%) patients had neck dissections. Five (7%) patients received adjuvant radiotherapy. Mean follow\u2010up was 42\u00a0months. Respective T1 and T2 5\u2010year Kaplan\u2010Meier estimates were: local control, 90% and 93%; loco\u2010regional control, 90% and 93%; disease specific survival, 90% and 93%; and overall survival, 94% and 93%. The average hospital stay was 2\u00a0days. Two (3%) patients experienced major complications. The overall laryngeal preservation rate was 95% (72 of 76).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>TLM is a safe and effective treatment in select carcinoma of the glottic larynx. Low morbidity and mortality and short periods of hospitalization make TLM an attractive therapeutic option.<\/jats:p><\/jats:sec><jats:sec><jats:title>SIGNIFICANCE<\/jats:title><jats:p>TLM is an emerging strategy in the treatment of laryngeal cancer.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2007.05.064","type":"journal-article","created":{"date-parts":[[2007,8,31]],"date-time":"2007-08-31T07:14:53Z","timestamp":1188544493000},"page":"482-486","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Transoral Laser Microsurgery for Untreated Glottic Carcinoma"],"prefix":"10.1002","volume":"137","author":[{"given":"David G.","family":"Grant","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Mayo Clinic Jacksonville Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John 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