{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T14:53:03Z","timestamp":1777733583981,"version":"3.51.4"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":3120,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The purpose of this study was to investigate the effectiveness of intratympanic dexamethasone injection as a protection agent against cisplatin\u2010induced ototoxicity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Setting<\/jats:title><jats:p>The four groups of guinea pigs were injected as follows: 1) cisplatin, 2) intratympanic dexamethasone, 3) cisplatin following intratympanic dexamethasone, and 4) cisplatin after intratympanic saline. Before and 3\u00a0days following injections, the ototoxic effect was measured with distortion product otoacoustic emissions (DPOAEs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The DPOAEs amplitudes and signal\u2010to\u2010noise ratio (SNR) values at 1 to 6\u00a0kHz frequencies for group 1 animals after injections significantly decreased over those before injections (<jats:italic>P<\/jats:italic> &lt; 0.05). In group 2, there were no significant differences in DPOAE amplitude and SNR values between before and after intratympanic dexamethasone injections (<jats:italic>P<\/jats:italic> &gt; 0.05). Considering group 3, there were also no significant differences in DPOAEs amplitudes and SNR values before and after of dexamethasone and cisplatin injections (<jats:italic>P<\/jats:italic> &gt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Intratympanic dexamethasone injection did not cause any ototoxic effect; in contrast, it might have a significant protective effect after cisplatin injection.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2007.05.068","type":"journal-article","created":{"date-parts":[[2007,11,14]],"date-time":"2007-11-14T07:12:14Z","timestamp":1195024334000},"page":"747-752","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":85,"title":["The protective effect of intratympanic dexamethasone on cisplatin\u2010induced ototoxicity in guinea 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