{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T15:55:50Z","timestamp":1761580550040,"version":"build-2065373602"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":3120,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To test the feasibility of contrast\u2010enhanced ultrasound (CEUS)\u2013guided sentinel lymph node biopsy (SNB) of the head and neck in a porcine model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Setting<\/jats:title><jats:p>In this prospective, non\u2010randomized study, methylene blue and Sonazoid were injected into the lateral tongue or floor of mouth (FOM) of four swine. Real\u2010time CEUS was used to identify contrast in the lymphatic channels flowing to the sentinel lymph node (SLN). Endoscopic or open SNB was performed. Neck dissection was then performed, and the residual nodal packet was examined for remaining contrast\u2010enhancing or blue dye\u2013stained nodes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all eight procedures, the SLN was visualized with ultrasound and blue dye. Seven procedures identified a single SLN, and one identified two SLNs. Subsequent neck dissections revealed no other nodes containing methylene blue or contrast in the nodal specimen or operative bed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion\/Significance<\/jats:title><jats:p>CEUS\u2010guided SNB of the head and neck in swine is feasible, with success comparable to blue dye\u2013guided SNB. This technique may offer several advantages over traditional techniques, and warrants further study.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2007.07.019","type":"journal-article","created":{"date-parts":[[2007,11,14]],"date-time":"2007-11-14T07:12:14Z","timestamp":1195024334000},"page":"735-741","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Ultrasound\u2010guided contrast\u2010enhanced sentinel node biopsy of the head and neck in a porcine model"],"prefix":"10.1002","volume":"137","author":[{"given":"Joseph M.","family":"Curry","sequence":"first","affiliation":[{"name":"Departments of Otolaryngology Head and Neck Surgery and Radiology Thomas Jefferson University Philadelphia PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esa","family":"Bloedon","sequence":"additional","affiliation":[{"name":"Departments of Otolaryngology Head and Neck Surgery and Radiology Thomas Jefferson University 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