{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:10:51Z","timestamp":1791173451667,"version":"4.1.0"},"reference-count":11,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":3090,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Seasonal allergic rhinitis (SAR) is a highly prevalent disease. This study was conducted to evaluate the onset and duration of action of three concentrations of olopatadine nasal spray.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>This was a randomized, double\u2010blind, single\u2010dose, placebo\u2010controlled study, conducted in an environmental exposure chamber in patients with SAR. A total of 320 patients were exposed to ragweed allergen in the chamber and randomized to olopatadine nasal spray 0.2%, 0.4%, 0.6%, or placebo nasal spray. Symptoms (sneezing, runny, itchy, and stuffy nose) were self\u2010assessed during a 12\u2010hour study period.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>All concentrations of olopatadine nasal spray provided clinically meaningful reductions in total nasal symptom scores at 30\u00a0minutes compared to the placebo. Olopatadine nasal spray 0.6% was significantly more effective (<jats:italic>P<\/jats:italic> &lt;0.05) than placebo nasal spray at all time\u2010points starting at 90\u00a0minutes postdose and continuing over 12 hours.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Olopatadine nasal spray 0.6% demonstrated a fast onset of action and maintained an effect for at least 12 hours after dosing.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2007.08.005","type":"journal-article","created":{"date-parts":[[2007,11,27]],"date-time":"2007-11-27T09:13:15Z","timestamp":1196154795000},"page":"918-924","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["An assessment of the onset and duration of action of olopatadine nasal spray"],"prefix":"10.1002","volume":"137","author":[{"given":"Piyush","family":"Patel","sequence":"first","affiliation":[{"name":"Allied Research International Mississauga Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter S.","family":"Roland","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center Dallas TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley F.","family":"Marple","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center Dallas TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Benninger","sequence":"additional","affiliation":[{"name":"Allied Research International Mississauga Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harriet","family":"Margalias","sequence":"additional","affiliation":[{"name":"Allied Research International Mississauga Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Brubaker","sequence":"additional","affiliation":[{"name":"Alcon Research, Ltd Fort Worth TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Drake","sequence":"additional","affiliation":[{"name":"Alcon Research, Ltd Fort Worth TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan L.","family":"Potts","sequence":"additional","affiliation":[{"name":"Alcon Research, Ltd Fort Worth TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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