{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T09:56:06Z","timestamp":1792058166769,"version":"4.4.0"},"reference-count":7,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the prevalence rate of otosyphilis and Lyme\u2010associated labyrinthine disease among patients presenting with idiopathic, progressive sensorineural hearing loss and, thus, to provide recommendations regarding the diagnostic workup.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>A prospective cohort study of patients presenting to a university hospital otology clinic with idiopathic, progressive sensorineural hearing loss between 1998 and 2006.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>Cases in which hearing loss was clearly attributable to other causes were excluded, leaving 181 patients (mean age 55.6 years). History, physical examination, autoimmune laboratory tests, syphilis and Lyme serology, audio\u2010metric assessment, and MRI were performed in all cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine cases (4.9%) of otosyphilis and none of Lyme disease were diagnosed by serological tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Routine serological testing for otosyphilis, but not Lyme disease, is recommended for all cases of idiopathic, progressive sensorineural hearing loss.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2007.10.012","type":"journal-article","created":{"date-parts":[[2008,9,10]],"date-time":"2008-09-10T20:24:56Z","timestamp":1221078296000},"page":"107-109","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Spirochetes in otology: Are we testing for the right pathogens?"],"prefix":"10.1002","volume":"138","author":[{"given":"Waleed M.","family":"Abuzeid","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology: Head and Neck Surgery University of Pennsylvania School of Medicine Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Ruckenstein","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology: Head and Neck Surgery University of Pennsylvania School of Medicine Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,1]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0196-0709(89)90037-9"},{"issue":"10","key":"e_1_2_7_3_1","first-page":"269","article-title":"Primary and secondary syphilis\u2014United States, 2003\u20132004","volume":"55","author":"Beltrami JF","year":"2006","journal-title":"CDC MMWR"},{"issue":"23","key":"e_1_2_7_4_1","first-page":"573","article-title":"Lyme disease\u2014United States, 2003\u20132005","volume":"56","author":"Bacon RM","year":"2007","journal-title":"In: CDC MMWR"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199106000-00004"},{"key":"e_1_2_7_6_1","first-page":"516","article-title":"Luetic endolymphatic hydrops: diagnosis and treatment","volume":"13","author":"Amenta CA","year":"1992","journal-title":"Am J Otol"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(05)70226-7"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348948609500308"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2007.10.012","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.otohns.2007.10.012","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2007.10.012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:36:24Z","timestamp":1760970984000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1016\/j.otohns.2007.10.012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1]]},"references-count":7,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["10.1016\/j.otohns.2007.10.012"],"URL":"https:\/\/doi.org\/10.1016\/j.otohns.2007.10.012","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1]]},"assertion":[{"value":"2007-08-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2007-10-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-01-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}