{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T06:35:12Z","timestamp":1782974112647,"version":"3.54.5"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>To determine the influence of gender and injection site on the amount of injectate needed to medialize an immobile vocal fold, and to describe the distribution patterns of the injected bolus.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN<\/jats:title><jats:p>Surgical intervention in human cadaveric larynges in experimental setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>SUBJECTS AND METHODS<\/jats:title><jats:p>Cadaveric larynges were injected with calcium hydroxylapatite into the lateral or medial aspect of the vocal fold. High\u2010resolution CT scans were obtained before and after injection.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Males required 50% to 60% more material than females (<jats:italic>P<\/jats:italic> = 0.03). For both genders, lateral injections required more than medial injections (<jats:italic>P<\/jats:italic> &lt; 0.001). Laterally injected boluses tended to distribute toward the cricothyroid space, with frank extrusions more common in females.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>The amount of injectate required to medialize male and female vocal folds is significantly different. The smaller size of the female larynx likely accounts for a higher incidence of extrusion through the cricothyroid space. These gender differences should be taken into consideration when performing injection laryngoplasty.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2007.10.028","type":"journal-article","created":{"date-parts":[[2008,1,31]],"date-time":"2008-01-31T11:08:16Z","timestamp":1201777696000},"page":"221-225","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Influence of gender and injection site on vocal fold augmentation"],"prefix":"10.1002","volume":"138","author":[{"given":"Ted","family":"Mau","sequence":"first","affiliation":[{"name":"Division of Laryngology Department of Otolaryngology\u2013Head and Neck Surgery University of California San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark S.","family":"Courey","sequence":"additional","affiliation":[{"name":"Division of Laryngology Department of Otolaryngology\u2013Head and Neck Surgery University of California San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1963.00750020187014"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949210100307"},{"key":"e_1_2_8_4_1","volume-title":"Phonosurgery: assessment and surgical management of voice disorders","author":"Ford CN","year":"1991"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2003.12.002"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0b013e3281084e61"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940411300114"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200310000-00028"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199912)21:8<743::AID-HED10>3.0.CO;2-8"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940111001213"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200105000-00001"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00463928"},{"key":"e_1_2_8_13_1","volume-title":"Professional voice: the science and art of clinical care","author":"Letson JA","year":"2005"},{"key":"e_1_2_8_14_1","first-page":"297","article-title":"Teflon injection of the vocal cord: a clinical and histopathologic study","volume":"9","author":"Schmidt PJ","year":"1980","journal-title":"J Otolaryngol"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1976.00780120080013"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199805000-00019"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2006.07.014"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459989310900318"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2007.10.028","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.otohns.2007.10.028","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2007.10.028","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:28:52Z","timestamp":1760970532000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1016\/j.otohns.2007.10.028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,2]]}},"alternative-id":["10.1016\/j.otohns.2007.10.028"],"URL":"https:\/\/doi.org\/10.1016\/j.otohns.2007.10.028","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,2]]},"assertion":[{"value":"2007-08-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2007-10-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-02-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}