{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:37:43Z","timestamp":1787647063623,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To report the efficacy of botulinum toxin A for radiation\u2010induced pain, trismus, and masticator spasm in head and neck cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>This prospective nonrandomized study included patients in complete remission with radiation\u2010induced pain and trismus with or without masticator spasms. Fifty units of Botox (Allergan) or 250 units of Dysport (Ipsen) were injected transcutaneously into the masseter muscles. Jaw opening was measured and patients answered 20 questions about jaw opening, pain, and cramps, before injection at 1\u00a0month.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nineteen patients (7 women, 12\u00a0men) were included. Median time after radiation therapy was 5 years (range, 11\u00a0months to 22 years). At 1\u00a0month, no significant increase in jaw opening was recorded. Improvement was noted in the functional domain (<jats:italic>P<\/jats:italic> = 0.004), for pain (<jats:italic>P<\/jats:italic> = 0.002) and cramps (<jats:italic>P<\/jats:italic> = 0.004), but not in the social (<jats:italic>P<\/jats:italic> = 0.83) or emotional (<jats:italic>P<\/jats:italic> = 0.43) domains. No side effects occurred.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Botulinum toxin did not improve trismus but significantly improved pain scores and masticator spasms (oromandibular dystonia).<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2007.12.021","type":"journal-article","created":{"date-parts":[[2008,3,25]],"date-time":"2008-03-25T00:19:43Z","timestamp":1206404383000},"page":"459-463","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":88,"title":["Botulinum toxin for radiation\u2010induced facial pain and trismus"],"prefix":"10.1002","volume":"138","author":[{"given":"M Hartl","family":"Dana","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Institut Gustave Roussy Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Fondation Ophtalmologique Adolphe de Rothschild Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juli\u00e9ron","family":"Morbize","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Institut Gustave Roussy Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Marandas","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Institut Gustave Roussy Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e9ois","family":"Janot","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Institut Gustave Roussy Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Bourhis","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Institut Gustave Roussy Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semradonc.2003.12.008"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4637.2006.00220.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000171019.80351.46"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000161354.28073.bc"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870100527"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.128.8.956"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.3.529"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-8467(02)00090-2"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005791623733"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.65.5.722"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348948909800202"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(200005)23:5<814::AID-MUS22>3.0.CO;2-V"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.46.1.259"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-8467(03)00044-1"},{"key":"e_1_2_10_16_1","first-page":"357","article-title":"Magnetic resonance imaging manifestations of radiation injury in brain stem and cervical spinal cord of nasopharyngeal carcinoma patients after radiotherapy.","volume":"24","author":"Song T","year":"2005","journal-title":"Ai Zenhg"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.9.2102"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1047-9651(03)00044-5"},{"key":"e_1_2_10_19_1","first-page":"329","article-title":"Nocturnal bruxism and temporo\u2010mandibular disorders","volume":"49","author":"Rugh JD","year":"1988","journal-title":"Adv Neurol"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.64.1.6"},{"key":"e_1_2_10_21_1","first-page":"459","article-title":"Respective potencies of Botox and Dysport: a double\u2010blind, randomised, crossover study in cervical dystonia","volume":"72","author":"Ranoux D","year":"2002","journal-title":"J Neurol Neurosurg Psychiatry"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2007.12.021","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.otohns.2007.12.021","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2007.12.021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:48:00Z","timestamp":1760953680000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1016\/j.otohns.2007.12.021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["10.1016\/j.otohns.2007.12.021"],"URL":"https:\/\/doi.org\/10.1016\/j.otohns.2007.12.021","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,4]]},"assertion":[{"value":"2007-08-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2007-12-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-04-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}