{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T10:13:05Z","timestamp":1792059185035,"version":"4.4.0"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:sec><jats:title>Study Design and Setting<\/jats:title><jats:p>A two\u2010center prospective case series analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>One hundred fourteen patients with previously treated laryngeal or pharyngeal squamous cell carcinoma who underwent salvage transoral laser microsurgery (TLM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Interventions<\/jats:title><jats:p>TLM in 114 patients, neck dissection in 22 (19%) patients, adjuvant radiotherapy in 12 (11%) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety\u2010one (80%) patients had recurrent primary tumors whereas 23 (20%) patients had second primary tumors occur within a previously irradiated field. The minimum follow\u2010up was 1 year (median, 3 years). The distribution of tumor location was oropharynx 52 (46%), glottic and subglottic larynx 44 (39%), supraglottic larynx 11 (10%), and pyriform\/hypopharynx 7 (6%). Overall, three\u2010year local and locoregional control estimates were 70 percent and 67 percent, respectively; and three\u2010year survival and disease\u2010free survival estimates were 62 percent and 64 percent, respectively. The average duration of hospitalization was 2.3\u00a0days. Four (3.5%) patients had significant postoperative bleeding. Two (&lt;2%) patients had treatment\u2010related deaths.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Transoral laser microsurgery offers select patients an attractive alternative salvage surgical therapy to the recurrent and second primary tumor site.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2007.12.046","type":"journal-article","created":{"date-parts":[[2008,6,11]],"date-time":"2008-06-11T05:39:14Z","timestamp":1213162754000},"page":"606-613","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Transoral laser microsurgery for recurrent laryngeal and pharyngeal cancer"],"prefix":"10.1002","volume":"138","author":[{"given":"David G.","family":"Grant","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Mayo Clinic Jacksonville Jacksonville FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John 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