{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:28:40Z","timestamp":1761006520441,"version":"build-2065373602"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare urinary leukotriene E4 (ULT) level in patients with nasal polyposis (NP) with and without aspirin intolerance and allergic rhinitis (AR), and correlate it with disease severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Setting<\/jats:title><jats:p>Prospective study from November 2005 to November 2006. Patients with NP (n = 30) and AR (n = 35) were included. The concentration of ULT was measured in both groups. Oral provocation test with aspirin was performed to patients with NP. ULT level between both groups was compared and correlated with NP disease severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>ULT concentration was elevated on NP and AR. The patients with NP and aspirin intolerance (n = 4) presented higher levels of ULT compared to aspirin\u2010tolerant patients. Leukotriene concentration was not correlated with NP severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with NP and aspirin intolerance have increased ULT excretion; thus their measurement can be used as an indicator of arachidonic acid metabolism alteration.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2008.02.001","type":"journal-article","created":{"date-parts":[[2008,6,11]],"date-time":"2008-06-11T05:39:14Z","timestamp":1213162754000},"page":"633-636","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Urinary leukotrienes in patients with nasal polyposis"],"prefix":"10.1002","volume":"138","author":[{"given":"Michel","family":"Royer","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Hospital Cl\u00ednico Universidad de Chile Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda 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