{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T10:39:19Z","timestamp":1768300759070,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to investigate the preventive effect of halofuginone on posterior glottic stenosis (PGS) in an animal model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>A randomized, controlled animal study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>Sixteen male New Zealand White rabbits were used for this study. After the mucosa of posterior glottis was removed for producing PGS, the study group (eight rabbits) was given intraperitoneal halofuginone at 0.1\u00a0mg\/kg\/day for 4 weeks and saline was injected into peritoneum in the control group. At 4 weeks after injury, postsurgical changes of posterior glottis were evaluated by gross and histologic examination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PGS was induced by the mucosal stripping of the posterior glottis. The halofuginone\u2010treated group showed less scarring and granulation tissue formation. Also, the degree of synechia was significantly less than that of control group. Histologic analysis showed the decreased fibrosis in the halofuginone\u2010treated group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study suggests that halofuginone can be helpful in preventing PGS after laryngeal injury.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2008.03.007","type":"journal-article","created":{"date-parts":[[2008,6,28]],"date-time":"2008-06-28T05:10:22Z","timestamp":1214629822000},"page":"94-99","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The preventive effect of halofuginone on posterior glottic stenosis in a rabbit model"],"prefix":"10.1002","volume":"139","author":[{"given":"Yeo\u2010Hoon","family":"Yoon","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Cancer Research Institute Chungnam National University College of Medicine Daejeon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki\u2010Sang","family":"Rha","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Cancer Research Institute Chungnam National University College of Medicine Daejeon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bon Seok","family":"Koo","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Cancer Research Institute Chungnam National University College of Medicine Daejeon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Yong","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Cancer Research Institute Chungnam National University College of Medicine Daejeon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong Min","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Cancer Research Institute Chungnam National University College of Medicine Daejeon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong Ho","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Cancer Research Institute Chungnam National University College of Medicine Daejeon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.1983.93.10.1314"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348948709600126"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198809000-00012"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459988008800625"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(99)70145-2"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940511400712"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-3623(97)00307-8"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1083-8791(03)00151-4"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(02)00164-2"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199804000-00021"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000091262.01493.e3"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000176551.09051.f2"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940611500511"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000250593.19282.47"},{"key":"e_1_2_8_16_1","first-page":"324","article-title":"Propofol in rabbits. 1. 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