{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T10:11:07Z","timestamp":1792059067364,"version":"4.4.0"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Nebulized budesonide (Pulmicort Respules, AstraZeneca, Wilmington, DE) provides control of respiratory tract inflammation in asthmatic patients. The Mucosal Atomization Device (MAD; Wolfe\u2010Tory Medical, Salt Lake City, UT) is a novel sinonasal atomization device.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Uncontrolled case series of postoperative patients with chronic rhinosinusitis (CRS) who received budesonide via MAD was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 44 patients with a mean age of 53.5 years met inclusion criteria. The average follow\u2010up was 31.5 weeks (SD 17.55; range, 8 to 80 weeks). Overall, patient and physician global assessments demonstrated moderate to significant improvement. Average daily oral prednisone usage among patients who took systemic steroids (n = 27) was reduced from 7.96 to 1.94\u00a0mg\/day without relapse of polyps, mucosal edema, and nasal discharge. Prednisone use was reduced to zero in 16 patients and reduced or stabilized in 10 other patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Topical budesonide via MAD may reduce the need for systemic prednisone and improve both physician and patient global assessment scores in postoperative CRS patients. Additional investigation is warranted to exclude placebo effect, spontaneous resolution, and regression to the mean as responsible factors for the reported findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.otohns.2008.03.009","type":"journal-article","created":{"date-parts":[[2008,6,28]],"date-time":"2008-06-28T05:10:22Z","timestamp":1214629822000},"page":"131-136","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Topical budesonide via mucosal atomization device in refractory postoperative chronic rhinosinusitis"],"prefix":"10.1002","volume":"139","author":[{"given":"Seth J.","family":"Kanowitz","sequence":"first","affiliation":[{"name":"private practice Morristown NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pete S.","family":"Batra","sequence":"additional","affiliation":[{"name":"Section of Nasal and Sinus Disorders Cleveland Clinic Head and Neck Institute Cleveland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin J.","family":"Citardi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery University of Texas Medical School Houston TX"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.09.029"},{"issue":"18","key":"e_1_2_9_3_1","first-page":"1","article-title":"European position paper on rhinosinusitis and nasal polyps.","volume":"43","author":"Fokkens W","year":"2005","journal-title":"Rhinology"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2006.01.006"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1444-0938.2002.tb03011.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6701895"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2006.03.009"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.12.8066"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2003.10.001"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2005.07.039"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200402000-00004"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2002.129738"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.2500\/105065898781390217"},{"key":"e_1_2_9_14_1","first-page":"57","article-title":"Efficacy and tolerability of budesonide aqueous nasal spray in chronic rhinosinusitis patients.","volume":"42","author":"Lund VJ","year":"2004","journal-title":"Rhinology"},{"key":"e_1_2_9_15_1","first-page":"185","article-title":"A randomized controlled trial showing efficacy of once daily intranasal budesonide in nasal polyposis.","volume":"38","author":"Filiaci F","year":"2000","journal-title":"Rhinology"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1081\/JAS-200038344"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)61285-9"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/hn.2003.v128.amhn0312811"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200005000-00010"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/194589240401800507"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000205218.37514.0f"},{"key":"e_1_2_9_22_1","unstructured":"Pulmicort Respules package insert June 2005.Available at:http:\/\/www.astrazeneca\u2010us.com\/pi\/pulmicortrespules.pdf. AccessedApril 7 2007."},{"key":"e_1_2_9_23_1","unstructured":"Rhinocort Aqua package insert January 2005.Available at:http:\/\/www.astrazeneca\u2010us.com\/pi\/Rhinocort_Aqua.pdf. AccessedApril 7 2007."},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.113.6.1693"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2008.03.009","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.otohns.2008.03.009","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2008.03.009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T08:49:38Z","timestamp":1760950178000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1016\/j.otohns.2008.03.009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["10.1016\/j.otohns.2008.03.009"],"URL":"https:\/\/doi.org\/10.1016\/j.otohns.2008.03.009","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.2530974.2177075","asserted-by":"object"}]},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,7]]},"assertion":[{"value":"2007-12-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-03-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-07-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}