{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T08:12:21Z","timestamp":1769501541437,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,7,24]],"date-time":"2018-07-24T00:00:00Z","timestamp":1532390400000},"content-version":"vor","delay-in-days":3552,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to identify the prognostic value of tumor markers in olfactory neuroblastoma (ONB).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Setting<\/jats:title><jats:p>Seventeen patients with ONB (23 tumor specimens) were included. Each specimen was studied for bcl\u20102, p53, MIC\u20102 by immunohistochemistry and for N\u2010myc by chromogenic in situ hybridization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twelve (70%) of 17 patients and 15 (65%) of 23 specimens showed positive reactivity for bcl\u20102. Of seven patients who were treated with neoadjuvant chemotherapy, one patient with diffuse bcl\u20102 expression achieved complete remission. Another patient without bcl\u20102 expression had no response to chemotherapy. Five patients who showed partial positivity achieved partial remission. Survival and bcl\u20102 expression tended to correlate, but it was not statistically significant (P = 0.06). All of the ONB specimens were negative for N\u2010myc. Positive immunoreactivity for MIC\u20102 or p53 was found only in one specimen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Bcl\u20102 expression was commonly found in ONB and the immunoreactivity for bcl\u20102\u00a0might predict response to neoadjuvant chemotherapy. In addition, Bcl\u20102 expression tended to be associated with worse survival.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2008.03.011","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T03:10:38Z","timestamp":1226286638000},"page":"708-712","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Expression of Bcl\u20102\u00a0in Olfactory Neuroblastoma and its Association with Chemotherapy and Survival"],"prefix":"10.1002","volume":"139","author":[{"suffix":"II","given":"Jeong\u2010Whun","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Seoul National University Bundang Hospital Seoul National University College of Medicine Seongnam Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gyu","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Seoul National University Bundang 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