{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T23:58:09Z","timestamp":1784937489430,"version":"3.55.0"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2008,8]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>To determine the efficacy of pantoprazole therapy for daytime somnolence, psychomotor vigilance, and quality of life in patients with mild\u2010moderate obstructive sleep disordered breathing (OSDB) and gastroesophageal reflux disease (GERD).<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN<\/jats:title><jats:p>Randomized, double\u2010blind, placebo\u2010controlled crossover trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Sixty patients with daytime sleepiness, mildmoderate OSDB and GERD were randomly assigned a 2\u2010week treatment with pantoprazole 40\u00a0mg or placebo followed by a 2\u2010week washout period and crossover respectively to 2\u2010week treatment with placebo or pantoprazole. Outcomes included Epworth Sleepiness Score (ESS), sleep\u2010related quality\u2010of\u2010life (FOSQ), and reaction time.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>With pantoprazole, patients reported statistically significantly greater improvement of overall reflux symptoms (<jats:italic>P<\/jats:italic> = 0.0003) and in ESS (<jats:italic>P<\/jats:italic> = 0.04). A significant improvement was noted in FOSQ for both treatments with a trend toward greater improvement with pantoprazole (<jats:italic>P<\/jats:italic> = 0.058). No improvement in reaction times was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Patients with coexistent GERD and OSDB noted significant improvement in daytime sleepiness after treatment with pantoprazole over placebo likely related to a reduction in nocturnal reflux\u2010related arousals.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2008.03.012","type":"journal-article","created":{"date-parts":[[2008,7,24]],"date-time":"2008-07-24T04:59:19Z","timestamp":1216875559000},"page":"286-290","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Randomized placebo\u2010controlled trial of pantoprazole for daytime sleepiness in GERD and obstructive sleep disordered breathing"],"prefix":"10.1002","volume":"139","author":[{"given":"Maria V.","family":"Suurna","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of Cincinnati College of Medicine Cincinnati OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff","family":"Welge","sequence":"additional","affiliation":[{"name":"Center for Biostatistical Services University of Cincinnati Cincinnati OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Surdulescu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Cincinnati College of Medicine Cincinnati OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Kushner","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Cincinnati College of Medicine Cincinnati OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Steward","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of Cincinnati College of Medicine Cincinnati 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