{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T15:32:42Z","timestamp":1781796762768,"version":"3.54.5"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2008,8]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>Hypoxia may result in increased recruitment of inflammatory cells and release of various inflammatory cytokines. Local hypoxia within the sinus is believed to aggravate sinus inflammation. In this study, we tried to investigate the correlation of hypoxia\u2010inducible factor, which is upregulated under hypoxic condition, and nasal polyposis.<\/jats:p><\/jats:sec><jats:sec><jats:title>SUBJECTS AND METHODS<\/jats:title><jats:p>Forty\u2010four polyps from patients undergoing endoscopic sinus surgery and 38\u00a0inferior turbinate mucosa were obtained for immunohistochemical staining. Twenty\u2010three polyps and 22 turbinate mucosa also underwent real\u2010time reverse transcription\u2010polymerase chain reaction for quantification of messenger RNA (mRNA). The severity of the disease was judged by the Lund\u2010Mackay CT scoring.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Expression of hypoxia\u2010inducible factor protein, but not mRNA, was significantly increased in nasal polyps compared with that in the turbinate mucosa, but it did not correlate with the disease severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>We suggest that hypoxia may have a role in the initiation of nasal polyposis.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2008.04.022","type":"journal-article","created":{"date-parts":[[2008,7,24]],"date-time":"2008-07-24T04:59:19Z","timestamp":1216875559000},"page":"206-210","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Expression of hypoxia\u2010inducible factor 1a in the nasal polyps by real\u2010time RT\u2010PCR and immunohistochemistry"],"prefix":"10.1002","volume":"139","author":[{"given":"Chen\u2010Yu","family":"Chien","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Kaohsiung Medical University Hospital Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih\u2010Feng","family":"Tai","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Kaohsiung Medical University Hospital Kaohsiung Taiwan"},{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Faculty of Medicine College of Medicine Kaohsiung Medical University Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuen\u2010Yao","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Kaohsiung Medical University Hospital Kaohsiung Taiwan"},{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Faculty of 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