{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:41:39Z","timestamp":1770338499146,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2008,8]]},"abstract":"<jats:sec><jats:title>OBJECTIVES<\/jats:title><jats:p>To investigate the expression and clinical significance of MMP\u20102, MMP\u20107, MMP\u20109, and TIMP\u20101\u00a0in patients with nasal polyposis (NP) and chronic rhinosinusitis (CRS).<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN<\/jats:title><jats:p>Prospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>SUBJECTS AND METHODS<\/jats:title><jats:p>This study involved 54 patients. There were three groups: nasal polyposis group, chronic rhinosinusitis group, and control group. Specimens were collected during endoscopic sinus surgery. Each sample was immunohistochemically examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Expression of MMP\u20102 was found significantly increased in NP, whereas MMP\u20107 expression was found significantly increased in CRS (<jats:italic>P<\/jats:italic> &lt; 0.001). TIMP\u20101 was significantly high in control group compared to CRS and NP (<jats:italic>P<\/jats:italic> &lt; 0.001 and <jats:italic>P<\/jats:italic> = 0.002, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Different regulation type of activation of MMPs has been found in these two diseases. If MMP\u20102 expression is intense in the mucosa, then this ends with polyp formation; if MMP\u20107 expression is intense, it ends with CRS or stays as CRS.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2008.04.032","type":"journal-article","created":{"date-parts":[[2008,7,24]],"date-time":"2008-07-24T04:59:19Z","timestamp":1216875559000},"page":"211-215","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["The expression of MMP\u20102, MMP\u20107, MMP\u20109, and TIMP\u20101\u00a0in chronic rhinosinusitis and nasal polyposis"],"prefix":"10.1002","volume":"139","author":[{"given":"Ilknur Haberal","family":"Can","sequence":"first","affiliation":[{"name":"ENT Clinic Ministry of Health Ankara Education and Training Hospital Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kursat","family":"Ceylan","sequence":"additional","affiliation":[{"name":"ENT Clinic Ministry of Health Ankara Education and Training Hospital Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muzaffer","family":"Caydere","sequence":"additional","affiliation":[{"name":"Pathology Clinic Ministry of Health Ankara Education and Training Hospital Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ethem Erdal","family":"Samim","sequence":"additional","affiliation":[{"name":"ENT Clinic Ministry of Health Ankara Education and Training Hospital Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huseyin","family":"Ustun","sequence":"additional","affiliation":[{"name":"Pathology Clinic Ministry of Health Ankara Education and Training Hospital Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Durdu Sertkaya","family":"Karasoy","sequence":"additional","affiliation":[{"name":"Department of Statistics Hacettepe University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1398-9995.2003.00364.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2003.18.1.97"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i40.6464"},{"key":"e_1_2_9_5_1","first-page":"607","article-title":"Recent advances in the regulation of matrix metalloproteinase 2 activation: from basic research to clinical implication (review)","volume":"9","author":"Yozhuzaki H","year":"2002","journal-title":"Oncol Rep"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2004.00516.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.PCC.0000192320.87416.1A"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2005-0344OC"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520510023963"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-6-151"},{"key":"e_1_2_9_11_1","first-page":"541","article-title":"Expression of matrix metallo\u2010proteinases and tissue inhibitors of metalloproteinase in uterine endometrial carcinoma and a correlation between expression of matrix metalloproteinase\u20107 and prognosis","volume":"16","author":"Misugi F","year":"2005","journal-title":"Int J Mol Med"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.127.6.1919"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2004.08.025"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9896(2000)9999:9999<::AID-PATH771>3.0.CO;2-W"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.6-5-415"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/13651820510042246a"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2006.00004.x"},{"issue":"6","key":"e_1_2_9_18_1","first-page":"1069","article-title":"Disulfiram suppresses invasive ability of osteosarcoma cells via the inhibition of MMP 2 and MMP 9 expression","volume":"40","author":"Cho HJ","year":"2007","journal-title":"Biochem Mol Biol"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.06-0082"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161207779313551"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2008.04.032","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.otohns.2008.04.032","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2008.04.032","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:02:05Z","timestamp":1760968925000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1016\/j.otohns.2008.04.032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["10.1016\/j.otohns.2008.04.032"],"URL":"https:\/\/doi.org\/10.1016\/j.otohns.2008.04.032","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,8]]},"assertion":[{"value":"2008-01-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-04-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-08-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}