{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T06:15:33Z","timestamp":1785392133280,"version":"3.55.0"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2008,8]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>To describe the effect of anterior tongue reduction surgery on tongue size, morphology, and histology.<\/jats:p><\/jats:sec><jats:sec><jats:title>DESIGN<\/jats:title><jats:p>Prospective experiment.<\/jats:p><\/jats:sec><jats:sec><jats:title>MATERIALS<\/jats:title><jats:p>Twenty\u2010two 12\u2010week\u2010old Yucatan minipigs.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Six sibling pairs had tongue reduction (Group B) or sham surgery (Group A), and underwent euthanasia the day of surgery. Five sibling pairs had tongue reduction (Group D) or sham surgery (Group C), and were raised for four weeks. Data collected included changes in tongue morphology, histology, and animal response to surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>All animals tolerated surgery and maintained their weight. Tongue size was uniformly reduced in all animals as compared to sham surgery. Tongue reduction was stable long term in Group D. All animals had normal wound healing and neuro\u2010vascular structure preservation. Fibrosis occurred at the repair site.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Midline tongue reduction resulted in uniform tongue reduction in all dimensions and volume, without damaging neurovascular structures. Localized fibrosis is a sequela of healing.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2008.05.018","type":"journal-article","created":{"date-parts":[[2008,7,24]],"date-time":"2008-07-24T04:59:19Z","timestamp":1216875559000},"page":"291-297","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Morphologic and histologic outcomes of tongue reduction surgery in an animal model"],"prefix":"10.1002","volume":"139","author":[{"given":"Jonathan A.","family":"Perkins","sequence":"first","affiliation":[{"name":"Division of Pediatric Otolaryngology Children's Hospital and Regional Medical Center Seattle WA"},{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of Washington Seattle WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volodymyr","family":"Shcherbatyy","sequence":"additional","affiliation":[{"name":"Department of Orthodontics University of Washington Seattle WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi\u2010Jun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthodontics University of Washington Seattle WA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000252256.77086.67"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2003.1"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2002.127583"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-5406(96)70105-1"},{"key":"e_1_2_8_6_1","first-page":"191","article-title":"Influence of surgical tongue reduction on pressure from the tongue on the teeth","volume":"63","author":"Frohlich K","year":"1993","journal-title":"Angle Orthod"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940611500809"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200410000-00009"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1996.01890150096017"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199305000-00031"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-199007000-00003"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1054\/bjps.1999.3311"},{"issue":"3","key":"e_1_2_8_13_1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1080\/00031305.1993.10475968","article-title":"Sample size as function of coefficient of variation and ratio of means","volume":"47","author":"Belle G","year":"1993","journal-title":"Am Stat"},{"key":"e_1_2_8_14_1","unstructured":"13.ShcherbatyyV PerkinsJA LiuZJFunctional deformations of the tongue following volume reduction. Anat Rec 2008: in press."},{"key":"e_1_2_8_15_1","unstructured":"14.LiuZJ ShcherbatyyV PerkinsJAFunctional loads of the tongue and consequence of the volume reduction. J Oral Maxillofac Surg 2008: in press."},{"key":"e_1_2_8_16_1","article-title":"Internal kinematics of the volume\u2010reduced tongue: a longitudinal study","volume":"87","author":"Shcherbatyy V","year":"2008","journal-title":"J Dent Res"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0185(19991201)256:4<412::AID-AR8>3.0.CO;2-5"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0185(20001201)260:4<378::AID-AR70>3.0.CO;2-A"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200102000-00005"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2008.05.018","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.otohns.2008.05.018","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2008.05.018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:02:08Z","timestamp":1760968928000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1016\/j.otohns.2008.05.018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["10.1016\/j.otohns.2008.05.018"],"URL":"https:\/\/doi.org\/10.1016\/j.otohns.2008.05.018","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,8]]},"assertion":[{"value":"2008-02-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-05-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-08-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}