{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T13:29:03Z","timestamp":1780147743816,"version":"3.54.0"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>To determine the efficacy of proton pump inhibitor (PPI) therapy with esomeprazole on symptoms and signs associated with laryngopharyngeal reflux (LPR).<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>Prospective, double\u2010blind, randomized, placebo\u2010controlled study. Sixty\u2010two patients with a reflux finding score (RFS) &gt; 7 and a reflux symptom index (RSI) &gt; 13 were enrolled and received either esomeprazole 20\u00a0mg twice daily or placebo for three months. RSI and RFS were assessed at baseline, after six weeks, and after three months.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Reductions of total RSI and RFS as well as of several subscores were significantly higher in the treatment group compared to placebo after three months (<jats:italic>P<\/jats:italic> &lt; 0.05 each). The difference between study groups was most pronounced for posterior commissure hypertrophy (<jats:italic>P<\/jats:italic> &lt; 0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>In the treatment of LPR\u2010related symptoms a high placebo effect can be observed. However, compared to control, twice\u2010daily PPI treatment for three months demonstrated a significantly greater improvement in laryngeal appearance and LPR symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2008.06.003","type":"journal-article","created":{"date-parts":[[2008,8,23]],"date-time":"2008-08-23T07:18:53Z","timestamp":1219475933000},"page":"414-420","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":124,"title":["Double\u2010blind, placebo\u2010controlled trial with esomeprazole for symptoms and signs associated with laryngopharyngeal reflux"],"prefix":"10.1002","volume":"139","author":[{"given":"Oliver","family":"Reichel","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Ludwig Maximilians University Munich 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