{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T22:30:56Z","timestamp":1775341856293,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>We evaluated the effect of endoscopic sinus surgery on irradiation\u2010induced rhinosinusitis of the maxillary\u2010sinus mucosa among patients with nasopharyngeal carcinoma (NPC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Surgical outcomes were evaluated by changes to the ultrastructure of the antral mucosa and nasomucociliary clearance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010one NPC patients with irradiation\u2010induced chronic sinusitis were enrolled in the study, along with five controls. Specimens were taken from 42\u00a0maxillary sinuses during surgery and 1 year after surgery. Saccharin transit time was measured before the initial surgery and 1 year after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the postoperative cases, we found a decrease in the number of the submucosal gland openings (<jats:italic>P<\/jats:italic> &lt; 0.05), the cilia in the antral mucosa regenerated (<jats:italic>P<\/jats:italic> &lt; 0.05), and the saccharin transit time reduced (<jats:italic>P<\/jats:italic> &lt; 0.05); the number of goblet cells did not change.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Endoscopic sinus surgery is an effective treatment for irradiation\u2010induced rhinosinusitis in NPC patients, improving ventilation and drainage of the paranasal sinuses, and facilitating regeneration of the sinus mucosa.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2008.07.006","type":"journal-article","created":{"date-parts":[[2008,9,25]],"date-time":"2008-09-25T04:36:38Z","timestamp":1222317398000},"page":"575-579","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Effect of endoscopic sinus surgery on irradiation\u2010induced rhinosinusitis in patients with nasopharyngeal carcinoma"],"prefix":"10.1002","volume":"139","author":[{"given":"Ko\u2010Hsin","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Keelung Hospital Department of Health National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan"},{"name":"Department of Otorhinolaryngology Taipei City Hospital Taipei Medical University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching\u2010Ting","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai\u2010Nan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya\u2010Jian","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Life Science National Taiwan University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hung\u2010Meng","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Taipei City Hospital Taipei Medical University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19830715)52:2<362::AID-CNCR2820520230>3.0.CO;2-V"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1017\/S002221510009681X"},{"key":"e_1_2_9_4_1","first-page":"428","article-title":"An experimental study of the mucociliary pathology of the eustachian tube in otitis media with effusion after irradiation","volume":"246","author":"Ohashi Y","year":"1989","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348948809700215"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949910800510"},{"key":"e_1_2_9_7_1","first-page":"729","article-title":"Histomorphological changes of ethmoid sinus mucosa in sinusitis patients with nasopharyngeal carcinoma after radiotherapy","volume":"12","author":"Si Y","year":"2005","journal-title":"Chin Arch Otolaryngol Head Neck Surg"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100132633"},{"key":"e_1_2_9_9_1","first-page":"577","article-title":"Functional endoscopic sinus surgery. 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