{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T17:53:26Z","timestamp":1760982806457,"version":"build-2065373602"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,7,24]],"date-time":"2018-07-24T00:00:00Z","timestamp":1532390400000},"content-version":"vor","delay-in-days":3552,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The impact of glucocorticoids and mineralocorticoids on chronic otitis media (COM) in toll\u2010like receptor 4\u2010deficient C3H\/HeJ mice was investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>To evaluate control of COM by steroids with differences in their anti\u2010inflammatory (prednisolone, dexamethasone), and fluid absorption functions (fludrocortisone, aldosterone). A minimum sample size of five animals for each group was required based on power analysis calculations. Sample sizes ranged from 7 to 17\u00a0mice per treatment group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>Auditory brain stem response (ABR) thresholds were performed at baseline, 2 weeks and 4 weeks. Histopathologic test results were evaluated on all mice ears at the end of the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Analysis of variance (ANOVA) of ABR threshold change showed significant treatment effects (P &lt; 0.05) by both steroid types at all time intervals and ABR frequencies except 4 weeks\/8\u00a0kHz. Histologic assessment showed prednisolone\u2010treated mice (62%) had a higher rate of clearance of middle and inner ear inflammation than control mice (4%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>It was concluded that steroid treatments can improve the physiology of chronic middle and inner ear disease seen with COM.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2008.07.029","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T03:10:38Z","timestamp":1226286638000},"page":"646-653","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Control of Chronic Otitis Media and Sensorineural Hearing Loss in C3H\/HeJ Mice: Glucocorticoids Vs Mineralocorticoids"],"prefix":"10.1002","volume":"139","author":[{"given":"Carol J.","family":"MacArthur","sequence":"first","affiliation":[{"name":"Oregon Hearing Research Center Department of Otolaryngology Head and Neck Surgery Oregon Health and Science University Portland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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