{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:37:34Z","timestamp":1761007054010,"version":"build-2065373602"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To test the feasibility of a novel contrast\u2010enhanced ultrasound (CEUS) technique, or lymphosonography, for sentinel node biopsy (SNB) of the supraglottis in a porcine model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Setting<\/jats:title><jats:p>In this prospective, non\u2010randomized animal study, blue dye and ultrasound contrast agent were injected into the supraglottis in seven 50\u2010kg Yorkshire swine. Transcutaneous CEUS was used to identify real\u2010time lymphatic flow of contrast through lymph channels (LC) to the sentinel lymph node (SLN). SNB was carried out, visually identifying a blue node, with the assistance of intraoperative CEUS. Bilateral modified radical neck dissections were performed to search for any residual contrast\u2010positive or blue SLNs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In each case, at least one SLN was identified by preoperative CEUS. A total of 12\u00a0nodes were identified on preoperative CEUS, and 11 of 12\u00a0nodes were stained with blue dye (91.7%). No residual blue or contrast\u2010positive nodes were identified on neck dissection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Lymphosonographic SNB of the supraglottis in a porcine model is technically feasible, and yields results comparable to traditional blue dye\u2013guided techniques. No \u201cshine\u2010through\u201d effect or nonsequential nodal enhancement occurred. This technique holds promise for sentinel node biopsy and allows a novel method for in vivo investigation of the lymphatic system.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2008.08.029","type":"journal-article","created":{"date-parts":[[2008,11,28]],"date-time":"2008-11-28T05:11:24Z","timestamp":1227849084000},"page":"798-804","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Lymphosonographic Sentinel node Biopsy of the Supraglottis in a Swine Model"],"prefix":"10.1002","volume":"139","author":[{"given":"Joseph M.","family":"Curry","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Thomas Jefferson University Philadelphia PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher R.","family":"Grindle","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Thomas Jefferson University 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