{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T18:41:09Z","timestamp":1780080069437,"version":"3.54.0"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2009,1]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>To investigate the perineural invasion in patients with squamous cell carcinoma of the larynx and hypopharynx.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN<\/jats:title><jats:p>A prospective study of patients with laryngeal and hypopharyngeal squamous cell carcinoma who underwent total or partial laryngectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Patients with squamous cell carcinoma of the larynx and pyriform sinus who underwent laryngectomy between 2002 and 2006\u00a0in the ENT Clinic of Cluj\u2010Napoca were investigated for histopathological identification of perineural invasion.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The present study included 256 patients. Perineural invasion was present in 86 cases out of the 256. Perineural invasion was detected in the major nerves of only one case out of 219 patients who had undergone total laryngectomy. The difference between the mean disease\u2010free survival of patients with or without perineural invasion of the minor nerves was statistically significant (Mann\u2010Whitney U test, <jats:italic>P<\/jats:italic> = 0.000102). The local recurrence rates in the cases with or without perineural invasion were significantly different (log\u2010rank test, <jats:italic>P<\/jats:italic> = 0.00001).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Major nerves do not constitute a way of spreading in the squamous cell carcinoma of the larynx and hypopharynx, whereas minor nerves remain a potential one.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2008.10.019","type":"journal-article","created":{"date-parts":[[2009,1,7]],"date-time":"2009-01-07T08:42:15Z","timestamp":1231317735000},"page":"65-69","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Perineural invasion of the major and minor nerves in laryngeal and hypopharyngeal cancer"],"prefix":"10.1002","volume":"140","author":[{"given":"Magdalena","family":"Chiril\u0103","sequence":"first","affiliation":[{"name":"ENT Department University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d Cluj\u2010Napoca Romania"},{"name":"ENT Section of the Emergency County Hospital Cluj\u2010Napoca Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sorana D.","family":"Bolboac\u0103","sequence":"additional","affiliation":[{"name":"Medical Informatics and Biostatistic Department University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d Cluj\u2010Napoca Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Cosgarea","sequence":"additional","affiliation":[{"name":"ENT Department University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d Cluj\u2010Napoca Romania"},{"name":"ENT Section of the Emergency County Hospital Cluj\u2010Napoca Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ermil","family":"Tomescu","sequence":"additional","affiliation":[{"name":"ENT Department University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d Cluj\u2010Napoca 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