{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T23:42:39Z","timestamp":1791243759716,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2009,3]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study evaluates the effects of uvulopalatopharyngoplasty (UPPP) on serum levels of nitric oxide derivatives (NO<jats:sub>x<\/jats:sub>) and endothelial function by endothelium dependent flow\u2010mediated dilation (FMD) in obstructive sleep apnea syndrome (OSAS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Prospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>Fifteen healthy subjects and 30 subjects with moderately severe to severe OSAS who desired UPPP were prospectively enrolled. FMD was measured by high\u2010resolution B\u2010mode ultrasonography; serum level of NO<jats:sub>x<\/jats:sub> from peripheral blood samples was also measured. All subjects participated in sleep studies. These studies were repeated 3\u00a0months after UPPP in OSAS patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For healthy patients, there was no difference in serum level of NO<jats:sub>x<\/jats:sub> and FMD between baseline and 3\u00a0months later. The serum levels of NO<jats:sub>x<\/jats:sub> in 14 of 30 patients with OSAS \u2013 designated surgical responders \u2013 increased from 13.9 \u00b1 5.5 \u03bcM preoperation to 28.9 \u00b1 8.2 \u03bcM postoperatively. FMD increased from 5.2 \u00b1 5.0 preoperatively to 10.0 \u00b1 4.7 postoperatively. For the 16 unresponsive patients, serum NOx and FMD remained impaired after UPPP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Successful treatment of OSAS with UPPP leads to restoration of FMD and normal serum levels of NO<jats:sub>x<\/jats:sub>.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2008.11.032","type":"journal-article","created":{"date-parts":[[2009,2,26]],"date-time":"2009-02-26T05:09:48Z","timestamp":1235624988000},"page":"369-374","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Effect of uvulopalatopharyngoplasty on endothelial function in obstructive sleep apnea"],"prefix":"10.1002","volume":"140","author":[{"given":"Mei\u2010Yu","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Nursing Mackay Medicine, Nursing and Management College Taipei Taiwan"},{"name":"Department of Otolaryngology Mackay Memorial Hospital Taipei 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