{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T15:13:35Z","timestamp":1760973215832,"version":"build-2065373602"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2009,3]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To establish the distance between tongue base salivary tissue and hyoid. Also, to identify protein differences between thyroglossal duct (TGD) remnants and salivary tissue in order to distinguish drainage source post Sistrunk surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods\/Setting<\/jats:title><jats:p>The anterior neck block was obtained from 10 adult cadavers with no known neck pathology. The distance between the normal salivary tissue and hyoid was measured histologically. Immunohistochemistry (IHC) was then performed on 20 archived tissue blocks from pediatric patients post Sistrunk surgery to identify the presence of amylase, MUC5AC (tracheobronchial mucin), and MUC7 (salivary mucin) within the excised specimen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Average distance between salivary tissue and the hyoid within adult human cadavers was 3.3\u00a0mm (range, 1.0\u20104.2\u00a0mm). IHC revealed all excised TGD remnants contained amylase and MUC5AC but none contained MUC7. Both amylase and MUC7 were present within adjacent salivary tissues.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Salivary tissue of the tongue base normally resides an average of 3.3\u00a0mm from the hyoid within the adult population. Biochemical analysis showed MUC5AC was specific for TGD remnants while MUC7 was specific for salivary tissue. Amylase does not distinguish between the two tissues.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2008.12.010","type":"journal-article","created":{"date-parts":[[2009,2,26]],"date-time":"2009-02-26T05:09:48Z","timestamp":1235624988000},"page":"343-347","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Drainage post\u2010thyroglossal duct remnant surgery: Possible source and analysis"],"prefix":"10.1002","volume":"140","author":[{"given":"Saraiza Abu","family":"Bakar","sequence":"first","affiliation":[{"name":"Massachusetts Eye and Ear Infirmary Harvard Medical School Boston MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Efrain A.","family":"Martinez\u2010Alvernia","sequence":"additional","affiliation":[{"name":"Massachusetts Eye and Ear Infirmary Harvard Medical School Boston MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leila A.","family":"Mankarious","sequence":"additional","affiliation":[{"name":"Massachusetts Eye and Ear Infirmary Harvard Medical School Boston MA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-192002000-00002"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(05)80097-1"},{"key":"e_1_2_9_4_1","first-page":"109","article-title":"Technique of removal of cysts and sinuses of the thyroglossal duct.","volume":"46","author":"Sistrunk WE","year":"1928","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1258\/002221503322334549"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(99)70054-9"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/10454411970080010301"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/10454411950060020501"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/10454411900010040201"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/002215540205000607"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.57.030195.003135"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/08959374000140011101"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M008850200"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M103554200"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e31806db531"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(20)80762-5"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00702348"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2008.12.010","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.otohns.2008.12.010","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2008.12.010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:39:48Z","timestamp":1760971188000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1016\/j.otohns.2008.12.010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["10.1016\/j.otohns.2008.12.010"],"URL":"https:\/\/doi.org\/10.1016\/j.otohns.2008.12.010","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"type":"print","value":"0194-5998"},{"type":"electronic","value":"1097-6817"}],"subject":[],"published":{"date-parts":[[2009,3]]},"assertion":[{"value":"2008-09-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-12-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-03-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}