{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T03:57:03Z","timestamp":1785902223926,"version":"3.56.0"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of the study is to ascertain the antifibrotic effect of topically applied halofuginone after acute subglottic injury.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>After standardized trauma to subglottic area, rats were divided into two groups: the study group that received treatment and the control group that did not. The subjects were treated with topical application of cottonoid soaked in 30\u00a0mg\/dL halofuginone solution for 5\u00a0minutes after subglottic trauma. The larynx specimens were examined histopathologically by light microscopy to assess fibrosis, epithelialization, inflammation, and necrosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The fibrosis indexes of the treated group were significantly less than those of the control group (<jats:italic>P<\/jats:italic> &lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Topically applied halofuginone hydrobromide decreases fibrosis\/scar tissue formation secondary to experimentally induced acute subglottic trauma.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2008.12.050","type":"journal-article","created":{"date-parts":[[2009,2,28]],"date-time":"2009-02-28T04:30:51Z","timestamp":1235795451000},"page":"720-723","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effectiveness of topically applied halofuginone in management of subglottic stenosis in rats"],"prefix":"10.1002","volume":"140","author":[{"given":"Eylem Ertug","family":"Ertu\u011frul","sequence":"first","affiliation":[{"name":"ENT Department G\u00fcneydo\u011fu Medical Center Diyarbakir Turkey"},{"name":"ENT Department GATA Haydarpasa Training Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130. 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