{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T06:04:17Z","timestamp":1790316257672,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:sec><jats:title>Rationale<\/jats:title><jats:p>Stimulation of interleukin\u201022 receptor alpha\u20101 (IL22RA1) was reported to increase the innate immune responses in inflammatory diseases. Moreover, a reduced level of IL22RA1 was found in patients with recalcitrant CRS with nasal polyps.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To explore association between single nucleotide polymorphisms (SNPs) in IL22RA1 and severe CRS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We extracted DNA from 206 cases with severe CRS and 196 postal code\u2013matched controls. Twenty\u2010three SNPs in the IL22RA1 gene were selected from the pooling\u2010based genome\u2010wide association study and from the CEU HapMap dataset and genotyped. PLINK software was used to determine association.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After Bonferroni correction, three SNPs (rs4292900 <jats:italic>P<\/jats:italic> <jats:sub>nom<\/jats:sub> = 0.0006, OR = 1.757; rs4648936 <jats:italic>P<\/jats:italic> <jats:sub>nom<\/jats:sub> = 0.0011, OR = 1.716; rs16829225 <jats:italic>P<\/jats:italic> <jats:sub>nom<\/jats:sub> = 0.0014, OR = 1.977) show significant differences in allelic frequencies between cases and controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Polymorphisms in IL22RA1 are associated with severe CRS. Replication and functional studies are involved to better understand the mechanism by which these polymorphisms contribute to the pathogenesis of CRS.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2008.12.058","type":"journal-article","created":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T04:19:29Z","timestamp":1235881169000},"page":"741-747","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Polymorphisms in the interleukin\u201022 receptor alpha\u20101 gene are associated with severe chronic rhinosinusitis"],"prefix":"10.1002","volume":"140","author":[{"given":"Leandra Mfuna","family":"Endam","sequence":"first","affiliation":[{"name":"Department of Otolaryngology H\u00f4tel\u2010Dieu Hospital Montreal University Montreal PQ Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohan","family":"Boss\u00e9","sequence":"additional","affiliation":[{"name":"Centre de Recherche H\u00f4pital Laval Institut Universitaire de Cardiologie et de Pneumologie de l'Universit\u00e9 Laval Quebec PQ Canada"},{"name":"Laval University Hospital Research Center (CRCHUL) Quebec PQ Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelali","family":"Filali\u2010Mouhim","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology H\u00f4tel\u2010Dieu Hospital Montreal University Montreal PQ Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chantale","family":"Cormier","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology H\u00f4tel\u2010Dieu Hospital Montreal University Montreal PQ Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Boisvert","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Saint\u2010Fran\u00e7ois d'Assise Hospital Quebec PQ Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis\u2010Philippe","family":"Boulet","sequence":"additional","affiliation":[{"name":"Centre de Recherche H\u00f4pital Laval Institut Universitaire de Cardiologie et de Pneumologie de l'Universit\u00e9 Laval Quebec PQ Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Hudson","sequence":"additional","affiliation":[{"name":"Ontario Institute for Cancer Research Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Desrosiers","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology H\u00f4tel\u2010Dieu Hospital Montreal University Montreal PQ Canada"},{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Montreal General Hospital McGill University Montreal PQ Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,5]]},"reference":[{"issue":"20","key":"e_1_2_9_2_1","first-page":"1","article-title":"European Position Paper on Rhinosinusitis and Nasal Polyps group. 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