{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T07:13:17Z","timestamp":1767597197768,"version":"build-2065373602"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Considering the different clinical aspects of polyps in asthmatic and nonasthmatic patients, we aimed to explore their histopathological characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Twenty\u2010five asthmatic patients and 25\u00a0nonasthmatic patients with polypoid chronic rhinosinusitis (29\u00a0male, 21 female; mean age 41.3 \u00b1 13.27; range 15\u201078 years) were enrolled in the study to be compared on the basis of histopathological characteristics. They were compared according to the following seven light microscopic findings: basement membrane thickness, goblet cell hyperplasia, subepithelial edema, submucous gland formation, eosinophilic infiltration, lymphocytic infiltration, and polymorphonuclear infiltration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Basement membrane thickening, goblet cell hyperplasia, and eosinophilic and lymphocytic infiltration were more prominent in the asthmatic compared with the nonasthmatic group (<jats:italic>P<\/jats:italic> &lt; 0.05), whereas polymorphonuclear infiltration was more prominent in nonasthmatics (<jats:italic>P<\/jats:italic> &lt; 0.05). No statistically significant differences were found between the two groups with regard to submucosal gland hyperplasia or subepithelial edema.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Asthmatic patients present histopathological characteristics of a marked chronic inflammatory reaction, which might explain the negative effect on chronic rhinosinusitis outcome and the severity of the disease in this group.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2009.01.027","type":"journal-article","created":{"date-parts":[[2009,3,18]],"date-time":"2009-03-18T04:53:14Z","timestamp":1237351994000},"page":"748-751","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["The comparison of histopathological characteristics of polyps in asthmatic and nonasthmatic patients"],"prefix":"10.1002","volume":"140","author":[{"given":"Mojtaba 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