{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:38:38Z","timestamp":1761007118426,"version":"build-2065373602"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate temporal bone CT findings in <jats:italic>GJB2<\/jats:italic>\u2010related deafness (DFNB1) hearing loss and non\u2010DFNB1 hearing loss children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Case\u2010control series.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>Children with nonsyndromic hearing loss diagnosed as DFNB1 or non\u2010DFNB1 after screening <jats:italic>GJB2<\/jats:italic> allele variants and the large <jats:italic>GJB6<\/jats:italic> deletion. Temporal bone CT images compared in a cohort of nine DFNB1 children with 10\u00a0non\u2010DFNB1 children. Visual criteria and absolute measurements were compared against established normative values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Visual inspection failed to identify two patients with abnormalities identified by using absolute measurements. Only one of nine DFNB1 children had an ear anomaly versus seven of 10\u00a0non\u2010DFNB1 (odds ratio 16.33; 95% CI, 1.35, 197.78; <jats:italic>P<\/jats:italic> = 0.050). The non\u2010DFNB1\u00a0group had a mean vestibule width that was significantly larger, and a mean lateral semicircular canal island width and vestibular aqueduct that were significantly smaller than the DFNB1\u00a0group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Visual inspection of temporal bone CT images alone may not identify all anomalies and should be used with absolute CT measurements. Abnormal temporal bone CT findings are significantly less likely in children with DFNB1 compared with non\u2010DFNB1 children despite similar age and degree of hearing loss.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2009.01.031","type":"journal-article","created":{"date-parts":[[2009,3,10]],"date-time":"2009-03-10T05:07:36Z","timestamp":1236661656000},"page":"665-669","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Imaging correlation of children with DFNB1 vs non\u2010DFNB1 hearing loss"],"prefix":"10.1002","volume":"140","author":[{"given":"Amit","family":"Kochhar","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Johns Hopkins University School of Medicine Baltimore MD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon I.","family":"Angeli","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of Miami Miller School of Medicine Miami FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandeep P.","family":"Dave","sequence":"additional","affiliation":[{"name":"Division of Pediatric Otolaryngology Miami Children's Hospital Miami FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue Z.","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of Miami Miller School of Medicine Miami FL"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.281.23.2211"},{"key":"e_1_2_9_3_1","first-page":"4387","volume-title":"Cummings Otolaryngology Head & Neck Surgery.","author":"Norton SJ","year":"2005"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.103.3.546"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)11071-1"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/16513860310003021"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e3180421718"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000244389.68568.a7"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10916"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00186783"},{"volume-title":"The Connexin\u2010deafness homepage.","year":"2007","key":"e_1_2_9_11_1"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012052"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2004.028324"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1086\/497996"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)71047-3"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2003.51"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2007.02.017"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e31817fb7ad"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.1978.88.5.723"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2007.4"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.82.3.257"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.127.9.1037"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2004.06.707"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.10330"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200002010-00016"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2009.01.031","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.otohns.2009.01.031","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2009.01.031","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:52:03Z","timestamp":1760961123000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1016\/j.otohns.2009.01.031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,5]]}},"alternative-id":["10.1016\/j.otohns.2009.01.031"],"URL":"https:\/\/doi.org\/10.1016\/j.otohns.2009.01.031","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"type":"print","value":"0194-5998"},{"type":"electronic","value":"1097-6817"}],"subject":[],"published":{"date-parts":[[2009,5]]},"assertion":[{"value":"2008-08-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-01-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-05-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}