{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T16:23:10Z","timestamp":1781713390203,"version":"3.54.5"},"reference-count":12,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:sec><jats:title>OBJECTIVES<\/jats:title><jats:sec><jats:label\/><jats:p>Tonsillectomy, with or without adenoidectomy, is one of the most common surgical procedures in pediatric otolaryngology. Despite its relative simplicity, pain is the main cause of morbidity in the postoperative period. We determined the effect of topical sucralfate on reduction of oropharyngeal pain in children submitted to adenotonsillectomy. Secondary outcomes were otalgia, analgesic use, type of diet, secondary bleeding, vomiting, fever, and weight loss.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN<\/jats:title><jats:p>Double\u2010blind, randomized clinical trial.<\/jats:p><\/jats:sec><\/jats:sec><jats:sec><jats:title>SETTING<\/jats:title><jats:p>Tertiary hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>SUBJECTS AND METHODS<\/jats:title><jats:p>Eighty\u2010two children of both sexes between four and 12 years old submitted to adenotonsillectomy were evaluated. They were allocated to receive topical sucralfate or placebo in intraoperative and postoperative periods four times a day for five days. Pain was measured through faces pain scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Reduction in oropharyngeal pain was significant with use of sucralfate during five days of evaluation (mean, 95% confidence interval, and <jats:italic>P<\/jats:italic> value); day 1: 2.05, 1.53\u20132.58, <jats:italic>P<\/jats:italic> = 0.000; day 2: 2.1, 1.51\u20132.70, <jats:italic>P<\/jats:italic> = 0.001; day 3: 1.44, 0.88\u20131.99, <jats:italic>P<\/jats:italic> = 0.003; day 4: 1.13, 0.58\u20131.55, <jats:italic>P<\/jats:italic> = 0.027; day 5: 0.67, 0.26\u20131.04, <jats:italic>P<\/jats:italic> = 0.021). There was no difference in secondary outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>We found beneficial effect of use of sucralfate in reduction of oropharyngeal pain in the postoperative period of adenotonsillectomy. However, topical sucralfate does not have a potent effect to the point of being utilized as a single analgesic treatment. Because it is simple, safe, tolerated, and low\u2010cost, it is an important tool as adjuvant treatment of post\u2010tonsillectomy pain.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2009.05.032","type":"journal-article","created":{"date-parts":[[2009,8,26]],"date-time":"2009-08-26T06:13:53Z","timestamp":1251267233000},"page":"322-328","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Topical Sucralfate in Post\u2010Adenotonsillectomy Analgesia in Children"],"prefix":"10.1002","volume":"141","author":[{"given":"Mauricio Schreiner","family":"Miura","sequence":"first","affiliation":[{"name":"Department of Medical Surgery of Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre and Division of Pediatric Otorhinolaryngology Hospital da Crian\u00e7a Santo Ant\u00eanio, Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias M\u00e9dicas\u2010Faculdade de Medicina da Universidade Federal do Rio Grande do Sul"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catia","family":"Saleh","sequence":"additional","affiliation":[{"name":"Department of Medical Surgery of Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre and Division of Pediatric Otorhinolaryngology Hospital da Crian\u00e7a Santo Ant\u00eanio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"de Andrade","sequence":"additional","affiliation":[{"name":"Department of Medical Surgery of Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre and Division of Pediatric Otorhinolaryngology Hospital da Crian\u00e7a Santo Ant\u00eanio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melina","family":"Assmann","sequence":"additional","affiliation":[{"name":"Department of Medical Surgery of Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre and Division of Pediatric Otorhinolaryngology Hospital da Crian\u00e7a Santo Ant\u00eanio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcio","family":"Ayres","sequence":"additional","affiliation":[{"name":"Industrial Pharmacy of Complexo Hospitalar Santa Casa de Porto Alegre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Faibes Lubianca","family":"Neto","sequence":"additional","affiliation":[{"name":"Department of Medical Surgery of Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre and Division of Pediatric Otorhinolaryngology Hospital da Crian\u00e7a Santo Ant\u00eanio, Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias M\u00e9dicas\u2010Faculdade de Medicina da Universidade Federal do Rio Grande do 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