{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T14:34:48Z","timestamp":1773844488894,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>To determine the significance of laryngopharyngeal reflux (LPR) in benign vocal mucosal lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND SETTING<\/jats:title><jats:p>A case\u2010control study at the tertiary referral medical center.<\/jats:p><\/jats:sec><jats:sec><jats:title>SUBJECTS AND METHODS<\/jats:title><jats:p>From April 2003 to December 2006, we studied 110 patients with benign vocal mucosal lesions who had undergone 24\u2010hour ambulatory double pH monitoring. The control group included 200 patients who had undergone ambulatory 24\u2010hour double\u2010probe pH monitoring due to laryngopharyngeal reflux\u2010related symptoms without specific findings of benign vocal mucosal lesions. Reflux symptom index and reflux finding score were measured. We compared the prevalence of pathologic laryngopharyngeal reflux and various parameters of the pH monitoring such as total reflux number, fraction time of pH below 4\u00a0in various positions, and DeMeester scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The prevalence of pathologic laryngopharyngeal reflux was 65 percent in the control group, 66 percent in vocal nodule group, 75 percent in the vocal polyp group, and 90 percent in the Reinke's edema group. Patients with Reinke's edema had a significantly higher prevalence of pathologic laryngopharyngeal reflux than controls (<jats:italic>P<\/jats:italic> = 0.016). LPR was associated with a significantly increased risk of Reinke's edema (odds ratio: 4.846, 95% confidence interval 1.093\u223c21.492). Total reflux number and DeMeester scores in the Reinke's edema group and fraction time of pH below 4\u00a0in the supine position in the vocal polyp group were significantly higher than those in the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Laryngopharyngeal reflux might play a role as an etiologic factor in Reinke's edema and vocal polyps.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2009.05.033","type":"journal-article","created":{"date-parts":[[2009,8,26]],"date-time":"2009-08-26T06:13:53Z","timestamp":1251267233000},"page":"369-373","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["The Significance of Laryngopharyngeal Reflux in Benign Vocal Mucosal Lesions"],"prefix":"10.1002","volume":"141","author":[{"given":"Jae Ho","family":"Chung","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery College of Medicine Hanyang University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung","family":"Tae","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery College of Medicine Hanyang University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong Seop","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery College of Medicine Hanyang University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Hyeok","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery College of Medicine Hanyang University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seok Hyun","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery College of Medicine Hanyang University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung Rae","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery College of Medicine Hanyang University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chul Won","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery College of Medicine Hanyang University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Soo","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine College of Medicine Hanyang University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","unstructured":"JohnMM.Update on the etiology diagnosis and treatment of vocal fold nodules polyps and cysts.Curr Opin Otolaryngol Head Neck Surg2003:456\u201361.","DOI":"10.1097\/00020840-200312000-00009"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949510400905"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.1991.tb01933.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","unstructured":"PowitzkyES.Extraesophageal reflux: the role in laryngeal disease.Curr Opin Otolaryngol Head Neck Surg2002:485\u201391.","DOI":"10.1097\/00020840-200212000-00013"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.1991.101.s53.1"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2002.125760"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-1997(02)00097-8"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200108000-00001"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00106-002-0801-y"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e3181651c3a"},{"key":"e_1_2_6_12_1","unstructured":"ReichelO HagedornH BerghausA.Diagnosis and treatment of laryngopharyngeal reflux.Laryngorhinootologie2006:919\u201324."},{"key":"e_1_2_6_13_1","first-page":"79","article-title":"The diagnosis of laryngopharyngeal reflux: the role of esophageal mucosal biopsy","volume":"49","author":"Tae K","year":"2006","journal-title":"Korean J Otolaryngol"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-005-1003-5"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200006000-00023"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940211100404"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:DDAS.0000004513.27054.d0"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199808000-00008"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.2310\/7070.2002.34517"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2009.05.033","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.otohns.2009.05.033","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2009.05.033","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T13:05:59Z","timestamp":1760965559000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1016\/j.otohns.2009.05.033"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,9]]}},"alternative-id":["10.1016\/j.otohns.2009.05.033"],"URL":"https:\/\/doi.org\/10.1016\/j.otohns.2009.05.033","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,9]]},"assertion":[{"value":"2009-03-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-05-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-09-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}