{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T23:00:19Z","timestamp":1781823619396,"version":"3.54.5"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2009,10]]},"abstract":"<jats:sec><jats:title>OBJECTIVES<\/jats:title><jats:p>Tonsillectomy, with or without adenoidectomy, is one of the most common surgical procedures in pediatric otolaryngology. Pain is the main cause of morbidity in the postoperative period, where it is serious in some cases, leading to odynophagia and resultant complications such as dehydration. We evaluated the effect of topical clindamycin in the reduction of oropharyngeal pain in children who underwent adenotonsillectomy. Secondary outcomes were otalgia, analgesic use, oral bacterial count, type of diet, secondary bleeding, vomiting, fever, and weight loss.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN<\/jats:title><jats:p>Double\u2010blind, randomized clinical trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>SETTING<\/jats:title><jats:p>Tertiary hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>SUBJECTS AND METHODS<\/jats:title><jats:p>Eighty\u2010two children of both sexes between four and 12 years of age who underwent adenotonsillectomy were allocated to receive topical clindamycin or placebo in the immediate preoperative, intraoperative, and eight\u2010to12\u2010hours postoperative periods. Pain was measured using a faces pain scale for five days.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Reduction of oropharyngeal pain was significant with the use of clindamycin only on the first postoperative day (95% confidence interval, 2.22 to 4.41 [clindamycin] vs 4.53 to 6.3 [placebo]; <jats:italic>P<\/jats:italic> =. 002). No difference was observed in the aerobic and anaerobic counts by tongue swab between premedication and third\u2010postoperative\u2010day samplings. There were no differences with respect to reduction in otalgia, paracetamol use, return to normal diet, variation in weight, secondary hemorrhage, vomiting, and fever.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>The use of topical clindamycin was beneficial in reducing pain on the first postoperative day, without effect on subsequent days. Future investigations could examine the use of topical clindamycin not only in the first 12 hours but also during five days of follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2009.06.082","type":"journal-article","created":{"date-parts":[[2009,9,27]],"date-time":"2009-09-27T04:09:43Z","timestamp":1254024583000},"page":"509-515","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Topical Clindamycin in Post\u2010Adenotonsillectomy Analgesia in Children: A Double\u2010Blind, Randomized Clinical Trial"],"prefix":"10.1002","volume":"141","author":[{"given":"Mauricio Schreiner","family":"Miura","sequence":"first","affiliation":[{"name":"Department of Medical Surgery of Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre and Division of Pediatric Otorhinolaryngology Hospital da Crian\u00e7a Santo Ant\u00f4nio, Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias M\u00e9dicas\u2010Faculdade de Medicina da Universidade Federal do Rio Grande do Sul Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catia","family":"Saleh","sequence":"additional","affiliation":[{"name":"Department of Medical Surgery of Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre and Division of Pediatric Otorhinolaryngology Hospital da Crian\u00e7a Santo Ant\u00f4nio Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"de Andrade","sequence":"additional","affiliation":[{"name":"Department of Medical Surgery of Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre and Division of Pediatric Otorhinolaryngology Hospital da Crian\u00e7a Santo Ant\u00f4nio Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melina","family":"Assmann","sequence":"additional","affiliation":[{"name":"Department of Medical Surgery of Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre and Division of Pediatric Otorhinolaryngology Hospital da Crian\u00e7a Santo Ant\u00f4nio Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc\u00e9lia Hernandes","family":"Lima","sequence":"additional","affiliation":[{"name":"Industrial Pharmacy of Complexo Hospitalar Santa Casa de Porto Alegre Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Faibes Lubianca Neto","sequence":"additional","affiliation":[{"name":"Department of Medical Surgery of Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre and Division of Pediatric Otorhinolaryngology Hospital da Crian\u00e7a Santo Ant\u00f4nio, Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias M\u00e9dicas\u2010Faculdade de Medicina da Universidade Federal do Rio Grande do Sul Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.5541121413"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5876(97)00107-9"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(99)00086-X"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(01)00314-1"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000446-200312000-00020"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1986.03780060022002"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MLG.0000163749.77019.8F"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2005.12.016"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD005607.pub2"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/170.3.729"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199406000-00011"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200102000-00026"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198801000-00007"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(99)70185-3"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(90)90018-9"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199211000-00007"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2009.06.082","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.otohns.2009.06.082","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2009.06.082","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T12:46:27Z","timestamp":1760964387000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1016\/j.otohns.2009.06.082"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,10]]}},"alternative-id":["10.1016\/j.otohns.2009.06.082"],"URL":"https:\/\/doi.org\/10.1016\/j.otohns.2009.06.082","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,10]]},"assertion":[{"value":"2009-02-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-06-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-10-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}