{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:03:18Z","timestamp":1761058998605,"version":"build-2065373602"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2009,10]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>To determine the influence of allergic rhinitis (AR) on the expression of matrix metalloproteinase (MMP)\u20109, MMP\u20102, and tissue inhibitor\u20101 of metalloproteinase (TIMP\u20101) in nasal polyposis.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN<\/jats:title><jats:p>A case\u2010control study.<\/jats:p><\/jats:sec><jats:sec><jats:title>SETTING<\/jats:title><jats:p>A tertiary referral center.<\/jats:p><\/jats:sec><jats:sec><jats:title>SUBJECTS AND METHODS<\/jats:title><jats:p>The expression of MMP\u20109, MMP\u20102, and TIMP\u20101 was investigated in the nasal polyp tissue (NP) and maxillary sinus mucosa (MM) samples from 20 AR patients and 20\u00a0nonallergic patients undergoing endoscopic sinus surgery. Trichrome, periodic acid\u2010Schiff, and hematoxylin\u2010eosin staining were also performed and those expression levels were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Infiltration of eosinophils was shown more intensely in NP rather than in MM, especially in the presence of AR. In the NP of AR patients, increased expression of MMP\u20109, MMP\u20102, and TIMP\u20101 was observed more prominently than in that of the control group. In case of MM, however, there was no significant difference between AR patients and the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>The presence of AR may enhance the expression of MMP\u20109, MMP\u20102, and TIMP\u20101 associated with airway remodeling in nasal polyposis.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2009.07.011","type":"journal-article","created":{"date-parts":[[2009,9,27]],"date-time":"2009-09-27T04:09:43Z","timestamp":1254024583000},"page":"442-447","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Nonasthmatic Nasal Polyposis Patients with Allergy Exhibit Greater Epithelial MMP Positivity"],"prefix":"10.1002","volume":"141","author":[{"given":"Hyun\u2010Woo","family":"Shin","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Seoul National University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doo Hee","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Seoul National University College of Medicine Seoul Korea"},{"name":"Institute of Allergy and Clinical Immunology Seoul National University Medical Research Center Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yune Sung","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Seoul National University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hye Jung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Seoul National University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong\u2010Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Seoul 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