{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T18:57:30Z","timestamp":1771700250216,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>To analyze auditory brainstem response (ABR) data in patients with vestibular schwannomas (VS) in an effort to identify correlations between abnormal ABR parameters and tumor size.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN<\/jats:title><jats:p>Cross\u2010sectional study with chart review.<\/jats:p><\/jats:sec><jats:sec><jats:title>SETTING<\/jats:title><jats:p>Tertiary referral hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>SUBJECTS AND METHODS<\/jats:title><jats:p>Retrospective chart review and analysis of bilateral ABR records in patients with VS. Interaural latency differences of interpeak I\u2010V (ILD\u2010I\u2010V) and ILD\u2010V longer than 0.2\u00a0ms were used as abnormal criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Thirty patients with a mean age of 50 \u00b1 14 years were included in this study. The most frequent changes in ABR parameters included those of ILD\u2010I\u2010V (100%), wave V latency (96.7%), ILD\u2010V (93.3%), and interpeak I\u2010V latency (90%). Average VS tumor size was 2.48 \u00b1 1.31\u00a0cm. For patients with VS greater than or equal to 2\u00a0cm, the prevalences of abnormal ipsilateral interpeak III\u2010V latency, contralateral wave V latency, and interpeak III\u2010V latency showed statically significant differences (<jats:italic>P<\/jats:italic> = 0.0035, <jats:italic>P<\/jats:italic> = 0.0267, and <jats:italic>P<\/jats:italic> = 0.0273, respectively) compared to those in patients with VS less than 2\u00a0cm. Tumor size was positively correlated with pure\u2010tone average (<jats:italic>P<\/jats:italic> = 0.0106) and with the total number of bilateral abnormal ABR parameters (<jats:italic>P<\/jats:italic> = 0.004).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>We identified a correlation between ABR parameters and VS tumor size. An ipsilateral ILD\u2010I\u2010V greater than 0.2\u00a0ms was sensitive for detecting VS. Abnormal contralateral wave V and interpeak III\u2010V latency indicated a tumor size potentially larger than 2\u00a0cm. Further studies are needed to confirm these findings.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2009.09.015","type":"journal-article","created":{"date-parts":[[2009,11,24]],"date-time":"2009-11-24T04:57:23Z","timestamp":1259038643000},"page":"695-700","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Ipsilateral and Contralateral Acoustic Brainstem Response Abnormalities in Patients With Vestibular Schwannoma"],"prefix":"10.1002","volume":"141","author":[{"given":"Chien","family":"Shih","sequence":"first","affiliation":[{"name":"Department of Otolaryngology National Taiwan University Hospital Yun\u2010Lin Branch Yun\u2010Lin Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fen\u2010Yu","family":"Tseng","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Te\u2010Hei","family":"Yeh","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology National Taiwan University Hospital Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuan\u2010Jen","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology National Taiwan University Hospital Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuh\u2010Shyang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Tai\u2010Tung Christian Hospital Tai\u2010Tung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100147292"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.131.3.241"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(95)70101-X"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1977.00780210037001"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199607000-00010"},{"key":"e_1_2_6_7_1","first-page":"127","article-title":"Normal hearing in acoustic neuroma patients: a critical evaluation","volume":"17","author":"Saleh EA","year":"1996","journal-title":"Am J Otol"},{"key":"e_1_2_6_8_1","first-page":"136","article-title":"Efficacy of auditory brainstem response as a screening test for small acoustic neuromas","volume":"16","author":"Gordon ML","year":"1995","journal-title":"Am J Otol"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/01945998941113P111"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003446-198604000-00008"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.127.1.19"},{"key":"e_1_2_6_12_1","first-page":"12","article-title":"Correlation of ABR and medical imaging in patients with cerebellopontine angle tumors","volume":"9","author":"Josey AF","year":"1988","journal-title":"Am J Otol"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489109130457"},{"key":"e_1_2_6_14_1","first-page":"118","article-title":"The effects of acoustic neuromas on ipsilateral and contralateral brainstem auditory evoked potentials during stimulation of the affected ear","volume":"4","author":"Zapulla RA","year":"1982","journal-title":"Am J Otol"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348948309200622"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198011000-00002"},{"key":"e_1_2_6_17_1","first-page":"253","article-title":"Auditory brainstem response wave IV\u2010V abnormalities from the ear opposite large cerebellopontine lesions","volume":"4","author":"Musiek FE","year":"1986","journal-title":"Am J Otol"},{"key":"e_1_2_6_18_1","first-page":"65","volume-title":"Handbook of Neurotological Diagnosis","author":"Johnson EW","year":"1987"},{"key":"e_1_2_6_19_1","first-page":"312","article-title":"Correlation of hearing loss and radiologic dimensions of vestibular schwannomas (acoustic neuromas)","volume":"17","author":"Nadol JB","year":"1996","journal-title":"Am J Otol"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016480701749240"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200011000-00015"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2009.09.015","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.otohns.2009.09.015","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2009.09.015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:09:16Z","timestamp":1760969356000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1016\/j.otohns.2009.09.015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["10.1016\/j.otohns.2009.09.015"],"URL":"https:\/\/doi.org\/10.1016\/j.otohns.2009.09.015","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,12]]},"assertion":[{"value":"2009-03-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-09-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-12-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}