{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T17:30:09Z","timestamp":1792949409459,"version":"4.5.0"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>Assess whether the presence of mucosal eosinophilia correlates with surgical outcomes in patients with chronic rhinosinusitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN<\/jats:title><jats:p>Prospective cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>SETTING<\/jats:title><jats:p>Tertiary medical center.<\/jats:p><\/jats:sec><jats:sec><jats:title>SUBJECTS AND METHODS<\/jats:title><jats:p>Adult patients with chronic rhinosinusitis were prospectively enrolled, and demographic data and medical comorbidities were recorded. Preoperative quality of life (QOL) was measured by the Chronic Sinusitis Survey (CSS), Rhinosinusitis Disability Index (RSDI), and Short Form\u201036 General Health Survey (SF\u201036). Sinus mucosal specimens were collected at the time of surgery and the degree of eosinophilia quantified. Postoperative QOL was measured, and differences in QOL improvement were compared between those with and without eosinophilia.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>A total of 102 patients had both histopathological and QOL outcome data available for review. Follow\u2010up averaged 16.5\u00a0months. Patients with eosinophilia showed significantly less improvement in the RSDI total (17.9 vs 25.0; <jats:italic>P<\/jats:italic> = 0.044), RSDI functional (5.7 vs 8.8; general health subscale; <jats:italic>P<\/jats:italic> = 0.018), CSS medication (3.6 vs 17.3; <jats:italic>P<\/jats:italic> = 0.013), SF\u201036 general health (0.6 vs 9.6; <jats:italic>P<\/jats:italic> = 0.008), SF\u201036\u00a0physical role (16.1 vs 34.7; <jats:italic>P<\/jats:italic> = 0.036), and SF\u201036 vitality (11.9 vs 21.2; <jats:italic>P<\/jats:italic> = 0.034) scales than those without eosinophilia. The greatest improvement in QOL was seen in patients without eosinophilia or polyps, with the least improvement seen in those with eosinophilia but without polyps.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>The presence of mucosal eosinophilia at the time of surgery consistently predicted less improvement in both disease\u2010specific and general QOL compared with patients without eosinophilia. The impact of eosinophilia on outcomes was greatest for patients without nasal polyposis, a group that demonstrated the least improvement in QOL measures.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2009.10.005","type":"journal-article","created":{"date-parts":[[2009,11,24]],"date-time":"2009-11-24T04:57:23Z","timestamp":1259038643000},"page":"64-71","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":205,"title":["Impact of Mucosal Eosinophilia and Nasal Polyposis on Quality\u2010of\u2010Life Outcomes after Sinus Surgery"],"prefix":"10.1002","volume":"142","author":[{"given":"Zachary M.","family":"Soler","sequence":"first","affiliation":[{"name":"Division of Rhinology and Sinus Surgery Department of Otolaryngology\u2010Head and Neck Surgery Oregon Sinus Center Portland OR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Sauer","sequence":"additional","affiliation":[{"name":"Department of Pathology Oregon Health and Science University Portland OR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jess","family":"Mace","sequence":"additional","affiliation":[{"name":"Division of Rhinology and Sinus Surgery Department of Otolaryngology\u2010Head and Neck Surgery Oregon Sinus Center Portland OR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy L.","family":"Smith","sequence":"additional","affiliation":[{"name":"Division of Rhinology and Sinus Surgery Department of Otolaryngology\u2010Head and Neck Surgery Oregon Sinus Center Portland 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