{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T11:52:40Z","timestamp":1771674760861,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the ability to detect the in vivo cochlear changes associated with vasopressin\u2010induced and surgically induced endolymphatic hydrops using MRI at 3 tesla (T).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Prospective, animal model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Animal laboratory.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>In group 1, five guinea pigs underwent post\u2013gadolinium temporal bone MRI before and after seven and 14\u00a0days of chronic systemic administration of vasopressin by osmotic pump. In group 2, five guinea pigs underwent temporal bone MRI eight weeks after unilateral surgical ablation of the endolymphatic sac. Three\u2010tesla high\u2010resolution T1\u2010weighted sequences were acquired pre\u2010 and postcontrast administration. Region of interest signal intensities of the perilymph and endolymph were analyzed manually. Quantitative evaluation of hydrops was measured histologically.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Gadolinium preferentially concentrated in the perilymph, allowing for distinction of cochlear compartments on 3.0\u2010T MRI. The T1\u2010weighted contrast MRI of vasopressin\u2010induced hydropic cochlea showed significant increases in signal intensity of the endolymph and perilymph. Surgically induced unilateral hydropic cochlea also showed increased signal intensity, compared with the control cochlea of the same animal, but less of an increase than the vasopressin group. The histological degree of hydrops induced in the vasopressin group was comparable to previous studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In vivo postcontrast MRI of the inner ear demonstrated cochlear changes associated with chronic systemic administration of vasopressin and surgical ablation of the endolymphatic sac. Understanding the MRI appearance of endolymphatic hydrops induced by various methods contributes to the future use of MRI as a possible tool in the diagnosis and treatment of M\u00e9ni\u00e8re's disease.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2009.10.006","type":"journal-article","created":{"date-parts":[[2010,1,16]],"date-time":"2010-01-16T04:16:06Z","timestamp":1263615366000},"page":"260-265","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Magnetic resonance imaging of guinea pig cochlea after vasopressin\u2010induced or surgically induced endolymphatic hydrops"],"prefix":"10.1002","volume":"142","author":[{"given":"Allen F.","family":"Marshall","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of North Carolina School of Medicine Chapel Hill NC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerie 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