{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T09:06:24Z","timestamp":1792055184530,"version":"4.4.0"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Understand the safety and outcomes of intratympanic gentamicin treatment in patients with M\u00e9ni\u00e8re's disease with normal hearing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Case series with chart review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Tertiary referral center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects and Methods<\/jats:title>\n                    <jats:p>\n                      A total of 224 patients with disabling M\u00e9ni\u00e8re's disease treated between May 1996 and June 2007 were grouped according to the American Academy of Otolaryngology\u2013Head and Neck Surgery (AAO\u2010HNS) 1995 Committee on Hearing and Equilibrium staging guidelines: stage 1 (&lt;25\u00a0dB pure\u2010tone average [PTA]); stage 2 through 4 (&gt;25\u00a0dB PTA). Patients underwent self\u2010treatment with intratympanic gentamicin (10\u00a0mg\/mL) three times daily for one to eight weeks. Outcome measures included pre\u2010 and post\u2010treatment speech discrimination score (SDS), PTA, electronystagmography, vertigo relief, and statistical analysis utilizing the Pearson \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty\u2010two (88%) of 24 patients with stage 1\u00a0M\u00e9ni\u00e8re's disease showed unchanged or improved SDS. All 24 patients showed a mean PTA loss of 8\u00a0dB. Seventeen (71%) patients reported complete or improved vertigo control. One hundred sixteen (59%) of 200 patients with stage 2 through 4\u00a0M\u00e9ni\u00e8re's disease showed unchanged or improved SDS. All 200 patients showed a mean PTA loss of 11\u00a0dB. One hundred forty\u2010eight (74%) patients reported complete or improved vertigo control.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with stage 1\u00a0M\u00e9ni\u00e8re's disease appear to have similar vertigo control with better hearing preservation than patients with advanced disease when treated with low\u2010dose intratympanic gentamicin (10\u00a0mg\/mL).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.otohns.2009.12.009","type":"journal-article","created":{"date-parts":[[2010,3,23]],"date-time":"2010-03-23T06:34:36Z","timestamp":1269326076000},"page":"570-575","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Intratympanic gentamicin treatment of patients with M\u00e9ni\u00e8re's disease with normal hearing"],"prefix":"10.1002","volume":"142","author":[{"given":"Herbert","family":"Silverstein","sequence":"first","affiliation":[{"name":"Ear Research Foundation a division of the Silverstein Institute Sarasota FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Wazen","sequence":"additional","affiliation":[{"name":"Ear Research Foundation a division of the Silverstein Institute Sarasota FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J.","family":"Van Ess","sequence":"additional","affiliation":[{"name":"Ear Research Foundation a division of the Silverstein Institute Sarasota FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Daugherty","sequence":"additional","affiliation":[{"name":"Ear Research Foundation a division of the Silverstein Institute Sarasota FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yadiel 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